| 基于N-羧甲基壳聚糖钆基磁共振造影剂的制备及性能 | |
| Preparation and Properties of N-Carboxymethyl Chitosan Gadolinium Contrast Agent | |
| 摘要: 通过在DTPA配体上修饰N-羧甲基壳聚糖(NCMCS)增加配体的分子量, 构建配合物Gd-(DTPA-NCMCS).测定了Gd-(DTPA-NCMCS)及对照组Gd-DTPA与Gd-(DTPA-CS)不同浓度的弛豫时间T1,拟合了配合物的纵向弛豫率r1,结果表明Gd-(DTPA-NCMCS)纵向弛豫能力明显强于Gd-DTPA,也高于配合物Gd-(DTPA-CS),浓度梯度的体外加权成像图清晰地观察到配合物Gd-(DTPA-NCMCS)比Gd-DTPA、Gd-(DTPA-CS)对应水溶液的信号更强.MTT法测定了Gd-(DTPA-NCMCS)的IC50值为568 μmol·L-1,表现出良好的生物相容性.Gd-(DTPA-NCMCS)可作为潜在的磁共振造影剂. | |
| 关键词: 磁共振造影 钆基造影剂 羧甲基壳聚糖 | |
| 基金项目: 国家自然科学基金(No.21401106),江苏省自然科学青年基金(No.BK20140090),南京晓庄学院校级科研项目(No.2013NXY03,2011NXY64)资助项目. | |
| Abstract: Complexes Gd-DTPA, Gd-(DTPA-CS) and Gd-(DTPA-NCMCS) were synthesized. The relaxation rate r1 of Gd-(DTPA-NCMCS), Gd-DTPA and Gd-(DTPA-CS) show that the longitudinal relaxation ability of Gd-(DTPA-NCMCS) is stronger than Gd-DTPA, and it is also higher than that of complex Gd-(DTPA-CS). T1-weighted images in vitro vs concentrations are consistent with the relaxation rates of the complexes. The IC50 value of Gd-(DTPA-NCMCS) is 568 μmol·L-1. Complex Gd-(DTPA-NCMCS) shows a good biocompatibility; and it can be used as a potential magnetic resonance imaging contrast agent. | |
| Keywords: magnetic resonance imaging gadolinium contrast agent carboxymethyl chitosan | |
| 投稿时间：2014-07-12 修订日期：2014-10-21 | |
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| 张长丽,顾费晨,陈昌云,陆国飞,蔡雯希.基于N-羧甲基壳聚糖钆基磁共振造影剂的制备及性能[J].无机化学学报,2014,30(12):2775-2780. | |
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