| 4-(3H)-喹唑酮Co(Ⅱ)、Ag(Ⅰ)配合物的合成、晶体结构、荧光和抗癌活性 |
| Syntheses, Structures, Fluorescence and Anticancer Activity of Co(Ⅱ) and Ag(Ⅰ) Complexes with 4-(3H)-Quinazolinone |
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| 摘要: 以4(3H)-喹唑酮、Co(NO3)2·6H2O、AgNO3为原料,在相同物料比、溶剂和常温条件下,合成了配合物[Co(L)2·(H2O)2·(NO3)2](1)和[Ag(L)2·(NO3)](2)(L=4-(3H)-喹唑酮).对其进行了X-射线单晶衍射表征和热重分析.X-射线单晶衍射分析表明,它们都属于三斜晶系,但1是六配位,2是三配位的.还测定了2的固体荧光和抗癌活性.配合物2的最大发射波长比配体红移了27nm,其对NCI(人非小细胞肺癌细胞)有较好的抗癌作用. |
| 关键词: 配合物 4-(3H)-喹唑酮 荧光 抗癌活性 |
| 基金项目: 桂林市科学研究与技术开发计划(No.20110330)和广西教育厅基础研究(No.200807MS090)资助项目 |
| Abstract: Complexes [Co(L)2(H2O)2(NO3)2] (1) and [Ag(L)2(NO3)] (2) were synthesized (L=4-(3H)-quinazolinone), and were both characterized by single crystal X-ray diffraction analysis and thermogravimetric analysis. Single crystal X-ray diffraction analysis showed that they all belong to triclinic space group, but 1 is six-coordinated and 2 is three-coordinated. Meanwhile, the solid-state fluorescence and anticancer activity of 2 also were studied. CCDC: 1011403, 1; 1011401, 2. |
| Keywords: complex 4-(3H)-quinazolinone fluorescence anticancer activity |
| 投稿时间：2014-08-30 修订日期：2014-10-29 |
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| 李石雄,廖蓓玲,罗培,蒋毅民.4-(3H)-喹唑酮Co(Ⅱ)、Ag(Ⅰ)配合物的合成、晶体结构、荧光和抗癌活性[J].无机化学学报,2015,31(2):291-296. |
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