| 1,3-二吗啉基丙烷与Hg(Ⅱ)和Zn(Ⅱ)的配合物:合成、结构与抗菌研究 |
| Complexation of 1,3-Dimorpholinopropane with Hg(Ⅱ) and Zn(Ⅱ) Salts: Syntheses, Crystal Structures and Antibacterial Studies |
| 作者 | 单位 | E-mail | | Goudarziafshar Hamid | Department of Chemistry, Faculty of Science, Sayyed Jamaleddinasadabadi University, Asadabad, Iran | hamid-gafshar@yahoo.com | | Yousefi Somaieh | Department of Chemistry, Faculty of Science, Ilam University, P.O. Box 69315516 Ilam, Iran | | | Abbasityula Yunes | Department of Chemistry, Lorestan University, Khorramabad, Iran | | | Dušek Michal | Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic | | | Eigner Václav | Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic | | | Rezaeivala Majid | Department of Chemical Engineering, Hamedan University of Technology, P.O. Box 65155 Hamedan, Iran | | | Özbek Neslihan | Department of Primary Education, Faculty of Education, Ahi Evran University, 40100 Krsehir, Turkey | |
|
| 摘要: 以1,3-二吗啉基丙烷(DMP)为配体合成了2个配合物:Hg(DMP)Cl2(1)和Zn(DMP)Cl2(2),并对其结构进行了表征。单晶X-射线结构分析表明,2个配合物中的金属离子都与2个N原子和2个Cl原子配位,形成扭曲四面体配位结构。配体和配合物对3种革兰氏阳性菌(S. aureus ATCC25923,E. faecalis ATCC23212和S. epidermidis ATCC34384)和3种革兰氏阴性菌(E. coli ATCC25922,P. aeruginosa ATCC27853和K. pneumonia ATCC70063)都具有抗菌活性,且在一定条件下,Hg(Ⅱ)配合物的抗菌活性超过了作为标准的磺胺异恶唑药物。 |
| 关键词: 晶体结构 1,3-吗啉基丙烷 抗菌活性 Hg(Ⅱ)配合物 Zn(Ⅱ)配合物 |
| 基金项目: Crystallography part was supported by the project (No.14-03276S) of the Czech Science Foundation. |
| Abstract: Two Hg(Ⅱ) (1) and Zn(Ⅱ) (2) complexes with general formulation M(DMP)Cl2 where DMP=1,3-dimorpholinopropane were synthesized and structurally characterized by physicochemical methods and single crystal X-ray diffraction. An X-ray structural analysis shows that in both complexes Hg and Zn are coordinated by two nitrogen and two chlorine atoms in a form of distorted tetrahedron. The ligand and related complexes have antibacterial activity against three Gram-positive bacteria (S. epidermidis ATCC25923, E. faecalis ATCC23212 and S. epidermidis ATCC34384), and also against the three Gram-negative bacteria (E. coli ATCC25922, P. aeruginosa ATCC27853 and K. pneumonia ATCC70063). The results revealed that in some cases the antibacterial activity of Hg(Ⅱ) complex exceeded the one of sulfisoxazole used as a standard. |
| Keywords: crystal structure 1,3-dimorpholinopropane antibacterial activity Hg(Ⅱ) complex Zn(Ⅱ) complex |
| 投稿时间：2015-01-26 修订日期：2015-03-30 |
| 摘要点击次数: 1931 |
| 全文下载次数: 2026 |
| Goudarziafshar Hamid,Yousefi Somaieh,Abbasityula Yunes,Dušek Michal,Eigner Václav,Rezaeivala Majid,Özbek Neslihan.1,3-二吗啉基丙烷与Hg(Ⅱ)和Zn(Ⅱ)的配合物:合成、结构与抗菌研究[J].无机化学学报,2015,31(6):1076-1084. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: |
|
|
|
|
|
|
