| 氢键构筑网络结构的三正丁基锡羧酸酯的合成、结构及抗癌活性 |
| Syntheses, Structures, Anti-tumor Activity of Tri(n-butyl)tin Carboxylates with Hydrogen-Bonded Network |
| 作者 | 单位 | E-mail | | 邝代治 | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 | hnkcq@qq.com | | 庾江喜 | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 | | | 冯泳兰 | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 | | | 张复兴 | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 | | | 蒋伍玖 | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 | | | 朱小明 | 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳师范学院化学与材料科学系, 衡阳 421008 | |
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| 摘要: 微波辐射条件下,μ-氧-双(三正丁基锡)分别与二苯乙醇酸、2-氯烟酸反应,合成了三正丁基锡羧酸酯(n-Bu)3SnO2CR(H2O)[R:C(OH)Ph2(1),C5NH3Cl(2)]。经IR、1H和13C NMR、元素分析及X-射线单晶衍射表征结构。配合物1、2均属正交晶系,空间群分别为Pbca和P212121,配基与中心锡原子均构成五配位畸变三角双锥构型。1和2晶体中,存在着多种氢键作用,分别连接扩展成二维和三维超分子网络。初步测试表明:1和2对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460增殖均有较强的抑制作用,尤其对MCF-7、Hela、NCI-H460的抑制作用均大大优于卡铂,且1的抗肿瘤活性更优于2。 |
| 关键词: 三正丁基锡羧酸酯 晶体结构 超分子网络 抗癌活性 |
| 基金项目: 湖南省自然科学基金(No.13JJ3112),湖南省科技计划(No.2014NK3086),湖南省高校创新平台开放基金(No.13K105,14K014)、重点实验室开放基金(No.13K01,GN14K01),湖南省“十二五”重点建设学科(材料物理与化学)和衡阳师范学院协同创新中心培育项目(No.12XT02)、青年骨干教师培养计划(2012)资助项目。 |
| Abstract: Two tri(n-butyl)tin carboxylates (n-Bu)3SnO2CR(H2O) (R: C(OH)Ph2 (1), C5NH3Cl (2)) were synthesized by the reactions of bis[tri(n-butyl)tin] oxide with benzilic acid and 2-chloronicotinic acid under microwave irradia-tion, respectively. Their structures were characterized by IR, 1H and 13C NMR, elemental analysis and X-ray single crystal diffraction. Both of the complexes belong to orthorhombic system, but their space groups are different. One is Pbca and the other is P212121. For each of them, the central tin atom is aberrant trigonal bipyramid with five-coordination. In their crystal structures, there are multi-hydrogen bonds, resulting in the formation of a 2D structure of 1 and a 3D supermolecular network of 2. The preliminary tests showed that both of which displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and especially for the later three, the complexes were much stronger than carboplatin, but the activity order was 1>2. |
| Keywords: tri(n-butyl)tin carboxylate crystal structure supermolecular network anti-tumor activity |
| 投稿时间：2014-11-14 修订日期：2014-12-15 |
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| 邝代治,庾江喜,冯泳兰,张复兴,蒋伍玖,朱小明.氢键构筑网络结构的三正丁基锡羧酸酯的合成、结构及抗癌活性[J].无机化学学报,2015,31(6):1112-1118. |
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