| Gd2(CO3)3:Eu@SiO2@APTES磁性-荧光双功能核壳微球的制备与性能 |
| Synthesis and Properties of Paramagnetic-Fluorescent Gd2(CO3)3:Eu@SiO2@APTES Core-Shell Structured Microspheres |
|
| 摘要: 采用尿素均相沉淀法和Stöber法制备了氨基化SiO2修饰的Gd2(CO3)3:Eu顺磁性-荧光双功能微球。用扫描电镜(SEM)、红外光谱(IR)、X-射线粉末衍射(XRD)等测试手段对微球的结构和颗粒特征进行了分析。结果表明:微球为核壳结构,其Gd2(CO3)3:Eu核平均直径为150nm左右,SiO2壳层的厚度大约为30nm,分散性良好。磁性测试显示微球拥有良好的顺磁性,荧光光谱表明,在396nm紫外光激发下,微球在613nm发射较强荧光,属于Eu3+的特征发射,同时微球能成功标记NCIH460肺癌细胞,MTT毒性测试表明该法制备的双功能微球在100~400μg·mL-1的浓度范围内无毒,表明其在生物应用方面的潜在应用价值。 |
| 关键词: 顺磁性 荧光 双功能微球 核壳结构 尿素均相沉淀法 |
| 基金项目: 江西省教育厅一般项目(No.GJJ14578,GJJ13216),江西省科技支撑项目(No.20142BBF60008)资助。 |
| Abstract: Monodisperse core-shell structured Gd2(CO3)3:Eu@SiO2@APTES microsphere was successfully prepared via the stöber method by coating a layer of silica on the surface of Gd2(CO3)3:Eu microspheres which derived from a simple urea assisted coprecipitation method. Their structural, optical and magnetic properties were investigated using SEM, TEM, XRD, FTIR, PL, and MPMS. The results indicated that the microspheres with general 30 nm shell thickness and 150 nm core size has spherical morphology with smooth surface and narrow size distribution. The paramagnetic property of the synthesized Gd2(CO3)3:Eu@SiO2@APTES microspheres were confirmed with its linear hysteresis plot (M-H). The synthesized microspheres can enter into living cancer cells and emit orange-red luminescence light due to the 5D0→7F2 transition of the Eu3+ ions, and Gd2(CO3)3:Eu@SiO2@APTES microspheres showed no cell cytotoxicity or adverse affect on kidney cell growth under high dose up to 400 μg·mL-1. Therefore, Gd2(CO3)3:Eu@SiO2@APTES microspheres provides the dual modality of optical and magnetic resonance imaging. |
| Keywords: paramagnetic fluorescent bifunctional microsphere core-shell structure urea assisted coprecipitation method |
| 投稿时间：2014-12-03 修订日期：2015-02-09 |
| 摘要点击次数: 1680 |
| 全文下载次数: 2736 |
| 吴燕利,徐贤柱,文佳,肖强,李永绣.Gd2(CO3)3:Eu@SiO2@APTES磁性-荧光双功能核壳微球的制备与性能[J].无机化学学报,2015,31(6):1125-1130. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: |
|
|
|
|
|
|
