| 二硫纶修饰的β-环糊精的自包合以及对金属离子的响应 |
| Maleonitriledithiolate Modified β-Cyclodextrin: Self-Inclusion and Response to Metal Ions |
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| 摘要: 利用圆二色光谱, 核磁, 等温滴定量热法和化学滴定方法研究单-6-马来二氰二硫代酸钠-β-环糊精在水溶液中的自包合性质。化学滴定实验结果表明十二烷基硫酸钠(SDS), Cu2+和Co2+可以改变单-6-马来二氰二硫代酸钠-β-环糊精的构象, 并且得出单-6-马来二氰二硫代酸钠-β-环糊精在水溶液中的存在形式是自包合的结论;Cu2+可以作为打开单-6-马来二氰二硫代酸钠-β-环糊精自包合结构的"钥匙", 使其构象改变后可以与中性红(NR)发生包合作用;加入EDTA与Cu2+配位后, 单-6-马来二氰二硫代酸钠-β-环糊精恢复自包合结构, 同时释放中性红客体分子。 |
| 关键词: 单-6-马来二氰二硫代酸钠-β-环糊精 圆二色 自包合 金刚烷胺 |
| 基金项目: 江苏省自然科学基金(No.BK2011550)资助项目。 |
| Abstract: The self-inclusion of maleonitriledithiolate-modified β-Cyclodextrin (mono[6-deoxy-6-(2-butene-dinitrile-2,3-dimercapto)]-β-Cyclodextrin, 6-mnt-β-Cyclodextrin) was studied by circular dichroism (CD) spectroscopy, 1H NMR spectroscopy, isothermal titration calorimetry (ITC), and chemical titration methods. Chemical titration results indicate that sodium dodecyl sulfate (SDS) is able to effectively dissociate the configuration of 6-mnt-β-Cyclodextrin, as well as Cu2+ and Co2+ do in solution. The experimental data suggest that 6-mnt-β-Cyclodextrin prefers self-inclusion in aqueous solution, which could be reversibly unlocked by metal ions. In its unlocked conformation, 6-mnt-β-Cyclodextrin is able to include Neutral Red (NR) and exhibits host-guest interactions. Upon removal of the "key" metal ion, 6-mnt-β-Cyclodextrin liberates the guest molecule and restores its self-inclusion. Therefore, the maleonitriledithiolate-modified cyclodextrin host exhibits potential to controllably uptake and release its guest by selected metal ion coordination. |
| Keywords: mono[6-deoxy-6-(2-butenedinitrile-2,3-dimercapto)]-β-Cyclodextrin circular dichroism self-inclusion Ada |
| 投稿时间：2015-04-03 修订日期：2015-05-11 |
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| 焦华晶,王琪,丁刘镠,芦昌盛.二硫纶修饰的β-环糊精的自包合以及对金属离子的响应[J].无机化学学报,2015,31(7):1269-1277. |
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| Support information: 相关附件： file150207_Supporting+Information+for+Publication.pdf |
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