| 双[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=5, 6)的合成、结构、热稳定性及生物活性 | |
| Syntheses, Crystal Structures, Thermal Stability and Biological Activities of Two Bis[tri(2-methyl-2-phenyl)propyltin]dicarboxylates (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=5,6) | |
| 摘要: 氧化双[三(2-甲基-2-苯基)丙基]锡分别与庚二酸和辛二酸反应, 合成了2个双[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2[(n=5 (1), 6 (2)], 经IR、1H和13C NMR、元素分析和X射线单晶衍射对化合物进行了表征。化合物属单斜晶系, 空间群为P21/c。锡原子均为畸型四面体构型, 化合物1以氢键作用形成一维链状结构, 化合物2以氢键和C-H…π作用形成二维网状结构。化合物1和2在340 ℃以下具有良好的热稳定性, 对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460均具有较好的体外抑制活性, 且具有一定的抑菌活性。 | |
| 关键词: 双[三(2-甲基-2-苯基)丙基锡]二元羧酸酯 合成 晶体结构 生物活性 | |
| 基金项目: 湖南省自然科学基金(No.13JJ3112)和科技计划(No.2013TZ2025, 2014NK3086, 2014FJ3060), 功能金属有机材料湖南省普通高校重点实验 室开放基金(No.13K105, 14K014, 13K01-05, GN14K01), 衡阳师范学院科学基金(No.12C45), 湖南省重点学科基金和湖南省高校科技创新 团队支持计划资助项目。 | |
| Abstract: The two bis[tri(2-methyl-2-phenyl)propyltin]dicarboxylates (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=5 (1), 6 (2)) have been synthesized by the reaction of pimelic acid and suberic acid with bis[tri(2-methyl-2-phenyl)propyltin]oxide, respectively. IR, 1H and 13C NMR, elemental analysis and X-ray diffraction for the title complexes were presented. The two complexes belong to monoclinic, space group P21/c. The tin atoms have a distorted tetrahedral geometry. A 1D chain structure of complex 1 is generated by intermolecular hydrogen bonds and a 2D network structure of complex 2 is formed by C-H…O and C-H…π interactions. The thermal gravimetric analysis has showed that the complexes 1 and 2 are stable below 340 ℃. The two complexes showed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and have antibacterial activity. | |
| Keywords: bis[tri(2-methyl-2-phenyl) propyltin] dicarboxylate synthesis crystal structure biological activitiy | |
| 投稿时间：2015-03-08 修订日期：2015-05-04 | |
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| 朱小明,邝代治,冯泳兰,张复兴,庾江喜,蒋伍玖,张志坚.双[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=5, 6)的合成、结构、热稳定性及生物活性[J].无机化学学报,2015,31(7):1373-1379. | |
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