| 两个吡咯酰腙铜配合物的制备、结构及抗肿瘤活性 | |
| Syntheses, Characterizations and Antitumor Activities of Two Copper(Ⅱ) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit | |
| 摘要: 合成并通过X-射线单晶衍射表征了2个铜配合物[Cu(H2L)2(THF)] (1)和[Cu2(L)Cl(CH3OH)]·H2O (2) (H3L=3,4-二甲基吡咯-5-甲酰基-2-甲酸乙酯-2-羟基-4-甲基苯甲酰腙)。结果表明在配合物1中, 中心金属离子与周围2个提供N2O配位原子的酰腙阴离子和1个四氢呋喃分子配位, 具有扭曲的四方锥配位构型。然而, 在双核配合物2中, 酰腙配体脱去3个质子, 通过NO和N2O2配位原子分别桥联2个具有平面正方形配位构型的铜中心。2个配合物对人肺癌细胞A549, 人食管癌细胞ECA109和人胃癌细胞SGC7901展现出显著的抗肿瘤活性。 | |
| 关键词: 酰腙 铜(Ⅱ)配合物 吡咯 抗肿瘤活性 | |
| 基金项目: 国家自然科学基金(No.21404033, 21401046, 21001040),河南省教育厅自然科学基金(No.12B150011, 14B150029), 河南理工大学博士基金 (No.72515/086, 61307/003) 和江苏省自然科学基金(No. BK20141122)资助项目。 | |
| Abstract: Two interesting copper(Ⅱ) complexes,[Cu(H2L)2(THF)] (1) and[Cu2(L)Cl(CH3OH)]·H2O (2) based on H3L {ethyl 5-[(2-hydroxyl-4-methylbenzoyl)amino-iminomethyl]-3,4-dimethyl-pyrrole-2-carboxylate} were synthesized and characterized by X-ray diffraction analyses. The results show that in complex 1, the copper(Ⅱ) ion is surrounded by two mono-deprotonated acylhydrazone ligands with NO donor sets and one THF molecule, and thus possesses a distorted square pyramidal geometry. However, in binuclear complex 2, the acylhydrazone ligand is tri-deprotonated and bridges two copper(Ⅱ) ions with square-planar coordination geometry through NO and N2O2 atom sets, respectively. Both complexes have excellent antitumor activities towards A549, ECA109 and SGC7901 cancer cells. | |
| Keywords: acylhydrazone Cu(Ⅱ) complex pyrrole antitumor activity | |
| 投稿时间：2015-04-01 修订日期：2015-05-12 | |
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| 韩学锋,蔡红新,贾磊,吴伟娜,张鑫,徐君,张照坡,王元.两个吡咯酰腙铜配合物的制备、结构及抗肿瘤活性[J].无机化学学报,2015,31(7):1453-1459. | |
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