| 二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2,3,4)的合成、结构及体外抗癌活性 | |
| Syntheses, Crystal Structures and in vitro Anti-tumor Activity of Three Bis[tris(2-methyl-2-phenyl)propyltin]dicarboxylate (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2, 3, 4) | |
| 摘要: 丁二酸、戊二酸和己二酸分别与μ-氧-双[三(2-甲基-2-苯基)丙基]锡反应,合成了3个二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2(1),3(2),4(3))。对化合物1~3进行了元素分析、红外光谱及核磁共振(1H,13C)表征,并通过X-射线晶体衍射分析测定晶体结构。化合物中锡与配基原子构成畸型四面体构型。试验表明,化合物2和3均对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460的增殖具有较强的抑制作用。 | |
| 关键词: 二[三(2-甲基-2-苯基)丙基锡]二元羧酸酯 合成 晶体结构 抗癌活性 | |
| 基金项目: 湖南省自然科学基金(No.13JJ3112)和科技计划(No.2013TZ2025,2014NK3086,2014FJ3060),功能金属有机材料湖南省普通高校重点实验室开放基金资助项目(No.13K105,14K014,13K01-05,GN14K01),衡阳师范学院科学基金(No.12C45),湖南省重点学科基金和湖南省高校科技创新团队支持计划,湖南省教育厅基金(No.15C0200,15C0200)资助项目。 | |
| Abstract: Three bis[tris(2-methyl-2-phenyl)propyltin] dicarboxylates (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2 (1), 3 (2), 4 (3)) have been synthesized by the reaction of succinic acid、glutaric and acid adipic acid with bis[tris(2-methyl-2-phenyl)propyltin] oxide, respectively. IR, 1H and 13C NMR, elemental analysis and X-ray diffraction for the title complexes were presented. The tin atoms of the three complexes have a distorted tetrahedral geometry. The tests showed the complexes 2 and 3 displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460. CCDC: 1042305, 1; 1042306, 2; 1409041, 3. | |
| Keywords: bis[tris(2-methyl-2-phenyl) propyltin] dicarboxylate synthesis crystal structure anti-tumor activity | |
| 投稿时间：2015-03-09 修订日期：2015-05-31 | |
| 摘要点击次数: 1544 | |
| 全文下载次数: 1966 | |
| 邝代治,朱小明,冯泳兰,张复兴,庾江喜,蒋伍玖,谭宇星,张志坚.二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2,3,4)的合成、结构及体外抗癌活性[J].无机化学学报,2015,31(10):2001-2007. | |
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