| 一个基于N'-(3-溴-5-氯-2-羟基苯亚甲基)-3-羟基-4-甲氧基苯甲酰肼的甲基麦芽酚配位的氧钒(Ⅴ)配合物:合成、晶体结构及其胰岛素增强活性 | |
| A Maltolato-Coordinated Oxovanadium(Ⅴ) Complex Derived from N'-(3-Bromo-5-chloro-2-hydroxybenzylidene)-3-hydroxyl-4-methoxybenzohydrazide: Synthesis, Crystal Structure, and Insulin-Enhancing Activity | |
| 摘要: 制备了1个芳酰腙化合物:N'-(3-溴-5-氯-2-羟基苯亚甲基)-3-羟基-4-甲氧基苯甲酰肼(H2L),并利用元素分析、红外、紫外、高分辨质谱、核磁共振氢谱和碳谱对其进行了表征。利用H2L与甲基麦芽酚和VO(acac)2在甲醇中反应得到了1个甲基麦芽酚配位的氧钒(Ⅴ)配合物[VO(mat)L]·MeOH。通过元素分析、红外和紫外光谱对其进行了表征,同时还研究了配合物的热稳定性。通过单晶X射线衍射进一步确认了H2L和配合物的结构。通过对C2C12肌细胞的胰岛素模拟实验,表明该配合物能显著促进细胞对葡萄糖的利用,其细胞毒性仅为0.07 g·L-1。 | |
| 关键词: 氧钒配合物 甲基麦芽酚 芳酰腙 晶体结构 胰岛素增强活性 | |
| 基金项目: 辽宁省自然科学基金(No.2015020673)、辽宁省高校优秀人才项目(No.LR2014032)和辽宁省大学生创新创业训练项目(No.201510165079) 资助。 | |
| Abstract: An aroylhydrazone compound, N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-hydroxyl-4-methoxyben-zohydrazide(H2L), was prepared and characterized by elemental analysis, IR, UV, HRMS, 1H NMR and 13C NMR spectrum. Reaction of H2L, maltol (3-hydroxy-2-methyl-4-pyrone) and VO(acac)2 in methanol afforded a maltolato-coordinated oxovanadium(Ⅴ) complex, [VO(mat)L]·MeOH. The complex was characterized by elemental analysis, IR and UV spectra. Thermal analysis was also performed. Structures of H2L and the complex were further confirmed by single crystal X-ray diffraction. Insulin-mimetic tests on C2C12 muscle cells indicate that the complex significantly stimulated cell glucose utilization with cytotoxicity at 0.07 g·L-1. CCDC: 1437202, H2L; 1437201, the complex. | |
| Keywords: oxovanadium complex maltol aroylhydrazone crystal structure insulin-enhancing activity | |
| 投稿时间：2015-11-18 修订日期：2015-12-21 | |
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| 李鹿曦,孙莹,谢青,孙宇冰,李坤华,李巍,由忠录.一个基于N'-(3-溴-5-氯-2-羟基苯亚甲基)-3-羟基-4-甲氧基苯甲酰肼的甲基麦芽酚配位的氧钒(Ⅴ)配合物:合成、晶体结构及其胰岛素增强活性[J].无机化学学报,2016,32(2):369-376. | |
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