| 芳酰腙铜(Ⅱ)和锌(Ⅱ)配合物的合成、晶体结构及抗菌活性 |
| Syntheses, Crystal Structures and Antimicrobial Activity of Copper(Ⅱ) and Zinc(Ⅱ) Complexes with Aroylhydrazones |
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| 摘要: 合成了一对结构类似的双核铜和锌配合物,Cu2(L1)2(1)和[Zn2(L2)2(CH3OH)2] (2),其中L1和L2分别是2-溴-N'-(2-羟基-5-甲基苯亚甲基)苯甲酰肼(H2L1)和2-氯-N'-(2-羟基-5-甲基苯亚甲基)苯甲酰肼(H2L2)的二价阴离子,通过元素分析、红外光谱以及单晶X射线衍射表征了它们的结构。配合物1以三斜晶系P1空间群结晶,其晶体学参数:a=0.91411(6) nm,b=1.18004(7) nm,c=1.35936(9) nm,α=101.928(2)°,β=91.399(2)°,γ=107.873(2)°,V=1.3593(2) nm3,Z=2,R1=0.0540,wR2=0.1189,GOF=0.970。配合物2以单斜晶系P21/c空间群结晶,其晶体学参数:a=1.21697(9) nm,b=1.21496(9) nm,c=1.21283(9) nm,β=110.939(1)°,V=1.6748(2) nm3,Z=2,R1=0.0341,wR2=0.0689,GOF=1.024。X射线分析表明2个化合物都是中心对称的双核配合物,其中配合物1中的Cu原子是平面正方形配位构型,配合物2中的Zn原子是四方锥配位构型。还通过MTT法研究了这两个配合物的抗细菌(大肠杆菌,金黄色葡萄球菌,枯草芽孢杆菌和铜绿色假单胞菌)和抗真菌(白假丝酵母菌和黑曲霉菌)活性。 |
| 关键词: 席夫碱 铜配合物 锌配合物 双核配合物 晶体结构 抗菌活性 |
| 基金项目: 河南省教育厅基金(No.14B150036)资助项目 |
| Abstract: A pair of structurally similar dinuclear copper(Ⅱ) and zinc(Ⅱ) complexes, Cu2(L1)2(1) and[Zn2(L2)2(CH3OH)2] (2), where L1 and L2 are the dianionic form of 2-bromo-N'-(2-hydroxy-5-methylbenzylidene)benzohyd-razide (H2L1) and 2-chloro-N'-(2-hydroxy-5-methylbenzylidene)benzohydrazide (H2L2), respectively, have been synthesized and characterized by elemental analysis, infrared spectra and single-crystal X-ray diffraction. Complex 1 crystallizes in the triclinic space group P1, with unit cell parameters:a=0.91411(6) nm, b=1.18004(7) nm, c=1.35936(9) nm, α=101.928(2)°, β=91.399(2)°, γ=107.873(2)°, V=1.3593(2) nm3, Z=2, R1=0.0540, wR2=0.1189, GOF=0.970. Complex 2 crystallizes as the monoclinic space group P21/c, with unit cell parameters:a=1.21697(9) nm, b=1.21496(9) nm, c=1.21283(9) nm, β=110.939(1)°, V=1.6748(2) nm3, Z=2, R1=0.0341, wR2=0.0689, GOF=1.024. X-ray analysis indicates that the complexes are centrosymmetric dinuclear species, with the Cu atoms in 1 in square planar coordination, and with the Zn atoms in 2 in square pyramidal coordination. The complexes were evaluated for their antibacterial (B. subtilis, S. aureus, E. coli and P. aeruginosa) and antifungal (C. albicans and A. niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. |
| Keywords: Schiff base copper complex zinc complex dinuclear complex crystal structure antimicrobial activity |
| 投稿时间：2016-01-13 修订日期：2016-03-11 |
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| 海士坤,娄淑芳,仇晓阳.芳酰腙铜(Ⅱ)和锌(Ⅱ)配合物的合成、晶体结构及抗菌活性[J].无机化学学报,2016,32(5):906-912. |
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