| 介孔硅酸镁改性硫酸钙骨水泥的降解及成骨性 | |
| Degradability and Osteogenesis of Mesoporous Magnesium Silicate Modified Calcium Sulphate Bone Cement | |
| 摘要: 将介孔硅酸镁(m-MS)掺杂到硫酸钙(CS)中,制备了一种新型复合骨水泥(m-MSC)。结果显示:掺入m-MS,延长了m-MSC的固化时间;提高了其降解速率;掺入m-MS可中和CS降解产生的酸性物质,缓解pH值下降。体外细胞实验显示:m-MSC能促进MC3T3-E1细胞增殖和分化;动物体内植入实验显示:m-MSC的成骨量和Ⅰ型胶原阳性表达率都显著高于CS。 | |
| 关键词: 介孔硅酸镁 硫酸钙 复合骨水泥 降解性 成骨性 | |
| 基金项目: 国家自然科学基金(No.81271705,31271031)和国家科技支撑计划(No.2013BAI05B10)资助项目。 | |
| Abstract: Anovel bone cement of mesoporous magnesium silicate and calcium sulfate composite (m-MSC) was fabricated by introducing mesoporous magnesium silicate (m-MS) into calcium sulfate bone cement (CS). The results showed that the addition of m-MSinto CSprolonged the setting time and promoted the degradability of the m-MSC, and neutralized acid substance produced by CSdegradation. In cell culture experiments, the result showed that the m-MSCcould promote the proliferation and differentiation of MC3T3-E1 cells. In addition, the results of m-MSChistological elevation from bone trauma model revealed that massive bony tissue and Col-Ⅰ formed were better than CSafter 12 weeks, indicating good osteogenesis of the m-MSC. | |
| Keywords: mesoporous magnesium silicate calcium sulfate composite bone cement degradability osteogenesis | |
| 投稿时间：2016-01-18 修订日期：2016-04-05 | |
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| 陈洁,董谢平,刘争卉,胡兴龙,魏杰.介孔硅酸镁改性硫酸钙骨水泥的降解及成骨性[J].无机化学学报,2016,32(6):935-944. | |
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