| 介孔钛纳米复合团簇应用于光热-光动力疗法 |
| Application of Mesoporous Titanium Composite Nanoclusters in Photothermal/Photodynamics Therapy |
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| 摘要: 采用水热法合成了一种新型的介孔二氧化钛/碳/亚甲蓝复合纳米团簇（TiO2@C-MB），并应用于肿瘤细胞的光动力（PDT）和光热治疗（PTT）。系统中介孔二氧化钛作为有效的光敏剂，MB作为重要的光敏添加剂以改善二氧化钛纳米晶的光化学效应，并将其光响应区域拓宽至光动力学疗法的理想治疗窗（650~900 nm）。柠檬酸在水热条件下被还原成碳并裹覆在二氧化钛表面。碳层表现出良好的光热效果，也充当多功能的电子受体以加速生成单线态氧。该纳米团簇不仅可以保持肿瘤细胞内部高浓度的MB和二氧化钛以产生大量的单线态氧杀死肿瘤细胞，而且可以避免MB退化失活。 |
| 关键词: 介孔钛纳米晶 纳米团簇 光动力疗法 光热治疗 联合抗肿瘤 |
| 基金项目: 安徽省教育厅自然科学研究重点项目（No.KJ2016A679），安徽省高校优秀人才支持计划重点项目（No.gxyqZD2016302），省级大学科研创新训练项目（No.201510375048，AH201310375053）；黄山学院科研项目（No.2006xkjq007）和安徽大学研究生学术创新研究项目（No.yqh100053）资助。 |
| Abstract: A novel mesoporous titanium dioxide/carbon/methylene blue composite nanocluster (TiO2@C-MB) was synthesized using hydrothermal method for photodynamic therapy (PDT) and photothermal therapy (PTT). The mesoporous TiO2 in this system was used as an effective photosensitizer, and MB served as a significant photosensitizer additive to improve the photochemistry effect of TiO2 nanocrystal and to widen the optical response area of TiO2 to the ideal therapeutic window (650~900 nm). Under hydrothermal conditions, citric acid was reduced into carbon and wrapped in the surface of TiO2, which showed an excellent photo-thermal effect, also acted as a versatile electron acceptor to accelerate the generation of singlet oxygen (1O2). The nanoclusters not only could retain a high concentration of TiO2 and MB within tumor cells to generate abundant 1O2 for killing tumour cell, but also could protect the MB from being degraded into an inactive form. |
| Keywords: mesoporous titanium nanocrystals nanocluster photodynamics therapy photothermal therapy Ccombined antitumor |
| 投稿时间：2016-01-29 修订日期：2016-06-13 |
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| 常贯儒,鲁信勇,裴春,陈龙,李召.介孔钛纳米复合团簇应用于光热-光动力疗法[J].无机化学学报,2016,32(7):1141-1148. |
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