喹啉-8-甲醛缩4-甲基氨基硫脲Ni(Ⅱ)/Zn(Ⅱ)/Cd(Ⅱ)/Cu(Ⅱ)配合物的合成、结构和DNA结合性质
Syntheses, Crystal Structures and DNA-Binding Properties of Ni(Ⅱ)/Zn(Ⅱ)/Cd(Ⅱ)/Cu(Ⅱ) Complexes with 4-Methyl-1-((quinolin-8-yl)methylene)-thiosemicarbazide
作者单位E-mail
毛盼东 河南理工大学化学化工学院, 焦作 454000  
韩学锋 河南理工大学人事处, 焦作 454000 108242720@qq.com 
李珊珊 河南理工大学化学化工学院, 焦作 454000  
史琳莹 河南理工大学化学化工学院, 焦作 454000  
王元 河南理工大学化学化工学院, 焦作 454000  
吴伟娜 河南理工大学化学化工学院, 焦作 454000 wuwn08@hpu.edu.cn 
摘要: 合成并通过单晶衍射、元素分析、红外光谱表征了配合物[NiL2]·2CH3OH(1),[ZnL2]·CH3OH(2),[CdL2]·CH3CH2OH(3)和[Cu2L2Cl2](4)(HL为喹啉-8-甲醛缩4-甲基氨基硫脲)。单晶衍射结果表明,配合物1~3结构相似,中心金属离子与来自2个硫醇化脱质子配体L-的4个N原子和2个S原子配位,采取扭曲的八面体配位构型。而配合物4中Cu(Ⅱ)离子与1个中性配体HL和3个氯离子配位,其中2个氯离子为μ2桥联。荧光光谱结果表明,所有配合物,尤其是4与DNA的相互作用能力明显强于配体。
关键词: 喹啉  缩氨基硫脲  配合物  晶体结构  DNA相互作用
基金项目: 国家自然科学基金(No.21001040)、河南省教育厅自然科学基金(No.12B150011,14B150029)资助项目。
Abstract: Four complexes[NiL2]·2CH3OH (1),[ZnL2]·CH3OH (2),[CdL2]·CH3CH2OH (3) and[Cu2L2Cl2] (4) (HL=4-methyl-1-((quinolin-8-yl)methylene)-thiosemicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction. The results show that the structures of complexes 1~3 are quite similar. The metal ion in each complex with a distorted octahedron geometry is surrounded by two anionic thiosemicarbazone ligands with N4S2 donor set. However, complex 4 is binuclear, and each central Cu(Ⅱ) ion is coordinated by one independent neutral ligand HL and three chloride anions, two of which act as μ2-bridges. In addition, the fluorescence spectra indicate that the interactions of the complex es with DNA, particularly of the complex 4, are stronger than that of the ligand HL.
Keywords: quinoline  thiosemicarbazone  complex  crystal structure  DNA interaction
投稿时间:2016-11-22 最后修改时间:2017-01-18
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毛盼东,韩学锋,李珊珊,史琳莹,王元,吴伟娜.喹啉-8-甲醛缩4-甲基氨基硫脲Ni(Ⅱ)/Zn(Ⅱ)/Cd(Ⅱ)/Cu(Ⅱ)配合物的合成、结构和DNA结合性质[J].无机化学学报,2017,33(4):692-698.
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