| 含吡嗪的缩氨基脲配体Ni(Ⅱ)/Cd(Ⅱ)配合物的晶体结构及与DNA的相互作用 | |
| Crystal Structures and DNA Interaction Properties of Ni(Ⅱ) and Cd(Ⅱ) Complexes with a Semicarbazone Ligand Bearing Pyrazine Unit | |
| 摘要: 合成配合物[NiL2]·CH3OH·0.5H2O（1）和[Cd（HL）Cl2]（2）（HL=3-甲基2-乙酰吡嗪缩4-苯基氨基脲）并通过单晶衍射、元素分析及红外光谱表征其结构。单晶衍射结果表明，配合物1中，Ni（Ⅱ）离子与2个拥有N2O电子供体的阴离子配体L-配位，配位构型为扭曲的八面体。而配合物2中，Cd（Ⅱ）离子与1个中性三齿配体HL和2个氯离子配位，拥有扭曲的四方锥配位构型。荧光光谱结果表明，配合物与DNA的相互作用强于配体。 | |
| 关键词: 缩氨基脲 镍配合物 镉配合物 吡嗪 晶体结构 DNA相互作用 | |
| 基金项目: 国家自然科学基金（No.21001040）、河南省科技厅基础与前沿项目（No.162300410011）、河南省教育厅自然科学基金（No.12B150011，14B150029）和河南省青年骨干教师项目（No.2014GGJS-045）资助。 | |
| Abstract: Two complexes, namely[NiL2]·CH3OH·0.5H2O (1) and[Cd(HL)Cl2)] (2) (HL=1-(3-methylpyrazin-2-yl)ethylidene-4-phenylsemicarbazide) have been synthesized and characterized by single crystal X-ray diffraction, elemental analysis and IR spectroscopy. X-ray diffraction analysis results show that the central Ni(Ⅱ) ion in complex 1 is surrounded by two independent anionic ligands with N2O donor set, thus possesses a distorted octahedral coordination geometry. However, in complex 2, the Cd(Ⅱ) ion with a distorted square pyramidal is coordinated with one neutral tridentate ligand HL and two chloride anions. In addition, the fluorescence spectra indicate that the interactions of the complexes with DNA are stronger than that of the ligand HL. CCDC 1479242:1; 1479243:2. | |
| Keywords: semicarbazone Ni(Ⅱ) complex Cd(Ⅱ) complex pyrazine crystal structure DNA interaction | |
| 投稿时间：2016-11-26 修订日期：2017-03-28 | |
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| 毛盼东,赵晓雷,邵志鹏,李敏,吴伟娜,王元.含吡嗪的缩氨基脲配体Ni(Ⅱ)/Cd(Ⅱ)配合物的晶体结构及与DNA的相互作用[J].无机化学学报,2017,33(5):890-896. | |
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