基于4-氟-N'-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼的甲基麦芽酚和乙基麦芽酚配位的氧钒(Ⅴ)配合物的合成、晶体结构及其类胰岛素活性
Syntheses, Crystal Structures and Insulin-like Activity of Maltolato-and Ethylmaltolato-Coordinated Oxovanadium(Ⅴ) Complexes Derived from 4-Fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide
作者单位E-mail
李玲 辽宁师范大学化学化工学院, 大连 116029  
吕凯文 辽宁师范大学化学化工学院, 大连 116029  
李运彤 辽宁师范大学化学化工学院, 大连 116029  
姜贵发 辽宁师范大学化学化工学院, 大连 116029  
辛雨 辽宁师范大学化学化工学院, 大连 116029  
叶蕾 辽宁师范大学化学化工学院, 大连 116029  
张岩 辽宁师范大学化学化工学院, 大连 116029  
刘慧 辽宁师范大学化学化工学院, 大连 116029  
商超男 辽宁师范大学化学化工学院, 大连 116029  
由忠录 辽宁师范大学化学化工学院, 大连 116029 youzhonglu@126.com 
摘要: 制备了一个芳酰腙化合物4-氟-N'-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼(H2L)。利用H2L和VO(acac)2分别与甲基麦芽酚(mat)和乙基麦芽酚(Emat)在甲醇中反应,得到了2个配合物[VO(L)(mat)](1)和[VO(L)(Emat)](2)。通过元素分析、红外光谱、紫外可见光谱和核磁共振氢谱表征了这些化合物的结构。通过单晶X射线衍射进一步确定了化合物的结构。芳酰腙配体以二价阴离子的方式通过酚羟基氧、亚胺基氮和烯醇氧原子与钒原子进行配位。在每个配合物中,钒都采取八面体配位构型。将配合物通过灌胃对正常的大鼠和四氧嘧啶糖尿病大鼠给药2周时间,结果表明这两个配合物在剂量为10.0和20.0 mgV·kg-1时可以显著降低四氧嘧啶糖尿病大鼠的血糖值,而对于正常大鼠的血糖值却没有改变。
关键词: 钒配合物  芳酰腙  晶体结构  类胰岛素活性
基金项目: 辽宁省自然科学基金(No.2015020673)和辽宁师范大学开放实验室(No.cx20160102)资助项目。
Abstract: A new aroylhydrazone compound 4-fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide (H2L) was prepared. Reaction of H2L and VO(acac)2 with maltol(mat) and ethylmaltol(Emat), respectively, in methanol afforded the complexes[VO(L)(mat)] (1) and[VO(L)(Emat)] (2). Both H2L and the oxovanadium complexes were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra. The structures of the compounds were further confirmed by single crystal X-ray diffraction. The aroylhydrazone ligand, in its dianionic form, coordinated to the V atoms through the phenolate oxygen, imino nitrogen and enolate oxygen. The maltol and ethylmaltol ligands coordinated to the V atoms through the carbonyl oxygen and deprotonated hydroxyl oxygen. The V atom in each complex is in octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgV·kg-1, can significantly decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.
Keywords: aroylhydrazone  oxovanadium(Ⅴ) complex  crystal structure  insulin-like activity
投稿时间:2017-02-20 最后修改时间:2017-03-22
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李玲,吕凯文,李运彤,姜贵发,辛雨,叶蕾,张岩,刘慧,商超男,由忠录.基于4-氟-N'-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼的甲基麦芽酚和乙基麦芽酚配位的氧钒(Ⅴ)配合物的合成、晶体结构及其类胰岛素活性[J].无机化学学报,2017,33(5):905-912.
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