| 阴阳离子聚氨酯/羟基磷灰石复合微球的制备及其自组装 |
| Preparation and Self-Assembly of Oppositely Charged Polyurethane/Hydroxypatite Microspheres |
| 作者 | 单位 | E-mail | | 赖欣 | 四川大学纳米生物材料研究中心, 分析测试中心, 成都 610064 | | | 侯毅 | 四川大学纳米生物材料研究中心, 分析测试中心, 成都 610064 | | | 李玉宝 | 四川大学纳米生物材料研究中心, 分析测试中心, 成都 610064 | | | 黄敏 | 四川大学纳米生物材料研究中心, 分析测试中心, 成都 610064 | | | 任欣 | 四川大学纳米生物材料研究中心, 分析测试中心, 成都 610064 | | | 张利 | 四川大学纳米生物材料研究中心, 分析测试中心, 成都 610064 | zhangli9111@126.com |
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| 摘要: 分别以2，2-双羟基丙酸（DMPA）和N-甲基二乙醇胺（MDEA）作扩链剂，采用自乳化法成功制备出带有正、负电荷的阳、阴离子聚氨酯/羟基磷灰石（PU/HA）微球，并考察HA的复合比例对微球形貌、理化性能的影响。在此基础上，通过微球间的静电作用力，将制备出的阴、阳离子复合微球自组装形成凝胶体系，并对其力学性能进行探究。SEM、ζ电位和激光粒度结果显示成功制备出具有一定形貌的带电微球，其中当扩链剂含量为15%（n/n）、HA含量为10%（w/w）时，微球形貌较佳且粒度分布均匀；X射线衍射、热分析结果表明，微球确为一定比例的HA与PU复合产物；自组装体系的流变学测试结果表明，微球组装后的产物呈类凝胶状态，具有较高的弹性模量，并有一定的可注射性。同时，骨髓间充质干细胞（BMSCs）可在组装材料表面粘附、铺展，生长良好。 |
| 关键词: 阴离子PU/HA微球 阳离子PU/HA微球 自乳化 自组装 可注射凝胶 |
| 基金项目: 国家自然科学基金（No.51673131，31370971）资助项目。 |
| Abstract: Oppositely charged polyurethane/hydroxyapatite (PU/HA) microspheres were successfully prepared by using the self-emulsifying method, in which 2,2-Bis(hydroxymethyl) propionic acid (DMPA) and N-Methyldietha-nolamine (MDEA) was used as chain extender, respectively. The self-assembled gel system was formed by electrostatic force between oppositely charged microspheres. The physicochemical properties of these microspheres were characterized and analyzed by means of SEM, Laser particle size analyzer, ζ potentiometer, XRD and TG, and the rheological properties of the self-assembled system was also studied by rheological test. The results confirm that oppositely charged microspheres are successfully prepared and the best morphology is obtained when the chain extender is 15% (n/n) and HA is 10% (w/w); XRD and TG results show that the inorganic phase of HA is successfully incorporated into PU microspheres. The rheological test demonstrate that the self-assembly gel system have higher elastic modulus and injectability. In addtion, the bone marrow mesenchymal stem cells (BMSCs) can adhere, spread and grow well on the surface of the material. |
| Keywords: anionic PU/HA microspheres cationic PU/HA microspheres self-emulsifying self-assembly injectable gel |
| 投稿时间：2017-02-28 修订日期：2017-06-02 |
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| 赖欣,侯毅,李玉宝,黄敏,任欣,张利.阴阳离子聚氨酯/羟基磷灰石复合微球的制备及其自组装[J].无机化学学报,2017,33(8):1403-1410. |
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