| 基于生物矿化的纳米载药体系 |
| Nanoparticle Drug Delivery Systems Based on Biominaralization |
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| 摘要: 基于生物矿化的纳米载药体系具有制备简单、良好的生物相容性和控制药物释放的能力、易被修饰且具备多功能性和靶向性等优点，在临床中拥有巨大的应用前景。本文系统阐述了基于生物矿化的纳米载体的构建原理和分类，重点介绍了它们的靶向性策略和刺激响应释放策略，并展望了其在临床治疗中的应用。 |
| 关键词: 生物矿化 纳米 载药体系 磷酸钙 |
| 基金项目: 国家自然科学基金（No.21625105）和浙江省自然科学基金（No.Y17B010009）资助项目。 |
| Abstract: Biominaralization based nanoparticle drug delivery systems that have the advantages of simple preparation, perfect biocompatibility, controlled drug release and easy to be modified have attracted a wide attention in field of clinical applications. This paper systematically elaborated the construction principle and classification of nanocarrier based on biomineralization, and the targeting strategy as well as stimulus response strategy of the caririers are discussed. The outlook of the clinical application is also prospected. |
| Keywords: biomineralization nanoparticle drug delivery calcium phosphate |
| 投稿时间：2017-07-20 修订日期：2017-09-11 |
| 摘要点击次数: 1754 |
| 全文下载次数: 1431 |
| 肖云,唐睿康.基于生物矿化的纳米载药体系[J].无机化学学报,2017,33(11):1937-1946. |
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