| 基于酰腙类Schiff碱的锌和镉配合物的合成、晶体结构和性质 |
| Syntheses, Crystal Structures and Properties of Zn(Ⅱ) and Cd(Ⅱ) Complexes with Acylhydrazone Schiff Base |
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| 摘要: 采用溶剂挥发法合成了配合物[M（HBrsth）2]（M=Zn（1），Cd（2），H2Brsth=5-溴水杨醛缩噻吩-2-甲酰腙）和配合物[Cd（L）2]（3，HL=2-乙酰基吡啶缩异烟酰腙），并经元素分析、红外光谱、紫外光谱和热重分析等对它们进行了表征。用X射线单晶衍射分析确定了配合物1和3的晶体结构，1属单斜晶系，C2/c空间群，呈现一维链状配位聚合结构；3属正交晶系，C2cb空间群。用MTT法测试了配合物对人肝肿瘤细胞HEPG2和人结肠癌细胞SW620的增殖抑制作用。还研究了配合物的发光性质。 |
| 关键词: 酰腙 配合物 晶体结构 发光性质 抗癌活性 |
| 基金项目: 泉州师范学院学科建设资金和福建省大学生创新创业训练计划项目（No.201610399011）资助。 |
| Abstract: The complexes of hydrazone Schiff base,[M(HBrsth)2](M=Zn (1), Cd (2)) and[Cd(L)2] (3), where H2Brsth is 2-thiophenecarboxylic acid (2-hydroxly-5-bromo-benzylidene)-hydrazide, HL is pyridine-4-carboxylic acid (pyridine-2-yl ethylidyne)-hydrazide, were respectively synthesized by slow evaporation methods in mixed-solvent, and characterized by elemental analysis, IR, UV-Vis, FL spectra and TGA. The structure of 1 and 3 has been accomplished by single crystal X-ray diffraction, which results confirm that the crystal of 1 belongs to the monoclinic system, space group C2/c with cell parameters a=2.315 4(4) nm, b=0.603 0(1) nm, c=1.911 2(4) nm, β=108.5(3)° and the crystal of 3 belongs to the orthorhombic system, space group C2cb with cell parameters a=0.988 6(2) nm, b=1.950 2(4) nm, c=1.244 0(2) nm. The antitumor activities in vitro against HEPG2 and SW620 cancer cells lines of complexes were tested by MTT method. In addition, fluorescent properties of three complexes were investigated. |
| Keywords: acylhydrazone complexes crystal structure fluorescence properties antitumor activity |
| 投稿时间：2017-06-08 修订日期：2017-10-19 |
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| 陈延民,冯英健,蔡明瑜,方雅倩,解庆范.基于酰腙类Schiff碱的锌和镉配合物的合成、晶体结构和性质[J].无机化学学报,2018,34(1):123-128. |
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