联合化疗与光动力治疗于一体的水溶性铜(Ⅱ)、镍(Ⅱ)酞菁的合成及体外抗癌活性
Water Soluble Cu(Ⅱ) and Ni(Ⅱ) Phthalocyanine: Syntheses and in Vitro Synergistic Anticancer Activities of Photodynamic Therapy and Chemotherapy Effects
作者单位E-mail
潘佳宝 山东大学晶体材料国家重点实验室, 济南 250100  
陈曦 山东大学晶体材料国家重点实验室, 济南 250100  
方文娟 山东大学晶体材料国家重点实验室, 济南 250100  
刘伟 山东大学晶体材料国家重点实验室, 济南 250100 weiliu@sdu.edu.cn 
于光伟 山东大学晶体材料国家重点实验室, 济南 250100  
摘要: 以邻苯二腈法合成了全水溶性铜酞菁(CuPc)6与镍酞菁(NiPc)7。对该类酞菁进行了光物理化学特性测试及体外细胞生物试验。结果表明:合成的铜酞菁6与镍酞菁7不仅水溶性好,而且对光热都十分稳定,并能有效产生单线态氧。体外细胞测试证实,铜酞菁6与镍酞菁7表现出了对癌细胞的避光下的抑制效应以及光照下的光动力治疗效应,显示了金属配合物化疗效应与光动力治疗的协同抗癌活性。
关键词: 铜酞菁  镍酞菁  单线态氧  光毒性
基金项目: 山东省自然科学基金(No.ZR2016BM16)和山东大学基础研究基金(No.2015JC036)资助项目。
Abstract: Water-soluble Cu(Ⅱ) phthalocyanine 6 and Ni(Ⅱ) phthalocyanine 7 were successfully synthesized starting from 1,2-dicynobenzen derivative. The photophysical and photochemical properties of these phthalocyanines show that they are not only very stable towards either heat or light, but also could yield singlet oxygen moderately. In vitro cell study demonstrates that both 6 and 7 could inhibit the growth of cancer cells in dark and also exhibit photodynamic therapy effect upon exposure to red light. These results show that these compounds have synergistic anticancer activities of photodynamic therapy and chemotherapy effects.
Keywords: Cu (Ⅱ) phthalocyanine  Ni (Ⅱ) phthalocyanine  singlet oxygen  phototoxicity
投稿时间:2017-10-31 修订日期:2018-03-30
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潘佳宝,陈曦,方文娟,刘伟,于光伟.联合化疗与光动力治疗于一体的水溶性铜(Ⅱ)、镍(Ⅱ)酞菁的合成及体外抗癌活性[J].无机化学学报,2018,34(5):889-896.
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