镁掺杂纳米羟基磷灰石的制备及其在载药方面的应用
Preparation and Drug Delivery Properties of Mg-Doped Hydroxyapatite Nanoparticles
作者单位E-mail
马晓雨 上海交通大学化学与化工学院, 上海 200240  
刘永佳 上海交通大学化学与化工学院, 上海 200240  
朱邦尚 上海交通大学化学与化工学院, 上海 200240
上海交通大学分析测试中心, 上海 200240 
bshzhu@sjtu.edu.cn 
摘要: 通过逐步沉淀反应一锅法制备了一系列不同含量的镁掺杂纳米羟基磷灰石。通过硝酸镁、硝酸钙不同的投料物质的量比调控纳米颗粒的形态和尺寸。通过透射电子显微镜(TEM)、X射线衍射(XRD)等分析手段对镁掺杂纳米羟基磷灰石进行物理化学性能表征,用MTT法评价其体外细胞毒性。研究结果表明:镁掺杂纳米羟基磷灰石呈现束状纳米纤维形态、比表面积大、细胞毒性较低;将其作为载体负载抗癌药物顺铂,具有很好的载药能力,载药量可达54%,该载药纳米颗粒还具备缓释特性(72 h释药量达到41.72%)和很好抑制癌细胞生长的效果。
关键词: 镁掺杂纳米羟基磷灰石  逐步反应法  顺铂  载药
基金项目: 国家自然科学基金(No.51373099)资助项目。
Abstract: Magnesium-doped hydroxyapatites nanoparticles (Mg-HAs) with different feeding molar ratios were synthesized by step precipitation reaction and one pot reaction. The morphology and size of the Mg-HAs were controlled by different feeding molar ratio of magnesium nitrate and calcium nitrate. The Mg-HAs were characterized by transmission electron microscope, X-ray diffraction, et al. MTT method was used to evaluated in vitro cytotoxicity of the Mg-HAs. Results show that the synthesized Mg-HAs had the frame with fiber like structure, high specific surface area and low cell cytotoxicity. Mg-HAs as drug carrier material and cisplatin (cDDP) as a model drug were investigated, and the max loading rate was 54.84%. The drug loading Mg-HAs also have release properties (the releasing rate is 41.72% after 72 h), and a better inhibitory effect on cancer cells.
Keywords: magnesium doped hydroxyapatite  step reaction  cisplatin  drug loading
投稿时间:2017-11-24 修订日期:2018-01-26
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马晓雨,刘永佳,朱邦尚.镁掺杂纳米羟基磷灰石的制备及其在载药方面的应用[J].无机化学学报,2018,34(5):917-924.
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