| 4-甲基-1，2，3-噻二唑-5-甲酸构筑的锌配合物的合成、晶体结构及与DNA作用 |
| Syntheses, Crystal Structures and DNA-Binding of Two Zinc(Ⅱ) Complexes Constructed by 4-Methyl-1,2,3-thiadiazol-5-carboxylic Acid |
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| 摘要: 由4-甲基-1，2，3-噻二唑-5-甲酸（HMTC，C4H4N2O2S）分别和1，3-双（4-吡啶基）-丙烷（bpp）、菲咯啉（phen）合成了2个锌配合物[Zn（MTC）2（bpp）]n（1）和[Zn（MTC）（phen）（H2O）2]（MTC）（2）。用元素分析、红外光谱、粉末X射线衍射、热重分析对配合物进行了表征，并通过单晶X射线衍射测定了配合物的晶体结构。结果表明：配合物1是二维网状结构，属于单斜晶系，P21/c空间群，中心金属锌（Ⅱ）离子的配位构型是扭曲的四面体结构。配合物2是二维层状结构，属于三斜晶系，P1空间群，中心金属锌（Ⅱ）离子的配位构型是变形的三角双锥结构。用溴化乙锭荧光探针法测定了配体和配合物对EB-DNA复合体系相互作用，实验结果显示无论配体还是配合物均能使EB-DNA复合体系发生不同程度的荧光猝灭，且配合物的作用强度远大于配体。 |
| 关键词: 4-甲基-1,2,3-噻二唑-5-甲酸 锌配合物 晶体结构 DNA作用 |
| 基金项目: 浙江省公益性技术应用研究计划项目（No.2014C32014）资助。 |
| Abstract: Two new zinc complexes[Zn(MTC)2(bpp)]n (1) and[Zn(MTC)(phen)(H2O)2](MTC) (2) (HMTC=4-methyl-1,2,3-thiadiazol-5-carboxylic, C4H4N2O2S; bpp=1,3-bis(4-pyridyl) propane; phen=1-10-phenanthroline) have been synthesized and characterized by single crystal X-ray diffraction, elemental analysis, IR spectra, PXRD and TG. The single crystal X-ray diffraction reveals that the complex 1 is two-dimensional network structure and crystallized in monoclinic with space group P21/c. Central Zn2+ is four-coordinated forming a distorted tetrahedron coordina-tion geometry. The complex 2 is two-dimensional layered structure and crystallized in triclinic with space group P1. Central Zn2+ is five-coordinated forming a distorted trigonal bipyramid coordination geometry. In addition, the interaction of complexes and ligand with EB-DNA were also studied by EtBr fluorescence probe. The interaction of complexes with DNA is stronger than ligand. |
| Keywords: 4-methyl-1,2,3-thiadiazol-5-carboxylic acid zinc complex crystal structure DNA-binding |
| 投稿时间：2017-11-20 修订日期：2018-01-11 |
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| 武大令,张敏芝,吴小勇,赵国良.4-甲基-1，2，3-噻二唑-5-甲酸构筑的锌配合物的合成、晶体结构及与DNA作用[J].无机化学学报,2018,34(5):973-980. |
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