三明治结构rGO/Fe3O4@mSiO2载体的构筑及协同抗肿瘤性能
Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers
作者单位E-mail
杨永梅 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601
黄山学院化学化工学院, 黄山 245041 
 
嵇眀翔 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601  
杨颖 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601  
谢安建 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601  
沈玉华 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601 s_yuhua@163.com 
摘要: 采用温和的反应条件,制备出三明治结构rGO/Fe3O4@mSiO2,利用SEM、TEM、FTIR、XRD和N2吸附-脱附等对其形貌和性能进行表征,考查了其对Hela细胞的毒性和细胞荧光成像效果,并探讨了其形成机理。实验结果表明:rGO/Fe3O4@mSiO2具有较高的比表面积(217 m2·g-1),对抗癌药物五氟尿嘧啶(5-FU)的载药率达到57.34%;它还具有较好的磁性,磁饱和强度为32 emu·g-1;而且rGO/Fe3O4@mSiO2纳米复合物在光照条件下具有优异的光热转换性能,对HeLa细胞表现出明显的杀伤效果。
关键词: 纳米复合材料  磁靶向  光热治疗  药物载体  协同抗癌
基金项目: 国家自然科学基金(No.21571002,21671001)和安徽省高校优秀青年骨干人才国内外访学项目(No.gxfx2017105)资助。
Abstract: A novel sandwich-like nanocomposites of rGO/Fe3O4@mSiO2 were successfully fabricated through a facile method. The morphology and properties of nanocomposites were characterized by SEM, TEM, FTIR, XRD and N2 adsorption-desorption. As a result, it was observed that the nanocomposites exhibit the saturation magnetization of 32 emu·g-1, and possess abundant pores with a large surface area as much as 217 m2·g-1. The loading capacity of Pentafluorouracil (5-FU) with the nanocomposites was high(57.34%). The formation mechanism of rGO/Fe3O4@mSiO2 was discussed. Additionally, the synergistic anticancer efficacy of as-prepared nanocomposites against HeLa cell line was investigated by MTT assay and cell fluorescence microscopic imaging analysis. The results indicated that 5-FU loaded in the nanocoposites is effectively delivered to tumor lesion sites under the action of magnetic targeting. Moreover, the rGO/Fe3O4@mSiO2 nanocomposites have excellent photothermal conversion properties under light conditions, and show significant killing effect on HeLa cells.
Keywords: nanocomposite  magnetic targeting  photo-thermal therapy  drug carrier  synergistic anti-cancer
投稿时间:2018-03-16 修订日期:2018-04-17
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杨永梅,嵇眀翔,杨颖,谢安建,沈玉华.三明治结构rGO/Fe3O4@mSiO2载体的构筑及协同抗肿瘤性能[J].无机化学学报,2018,34(6):1095-1102.
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