| 生物活性配体喹啉-2-羧酸根锰(Ⅱ)配位聚合物的晶体结构及生物活性 | |
| Crystal Structure and Bioactivities of Mn(Ⅱ) Coordination Polymer with Biological Ligand of 2-Quinolinecarboxylic-carboxylate | |
| 摘要: 合成了一个喹啉-2-羧酸根锰配位聚合物{[Mn（Qina）2（Bpp）]·2/3H2O}n，（Qina=2-quinolinecarboxylic-carboxylate，Bpp=4，4'-trimethylenedipyridine）并制得其单晶。运用元素分析、红外光谱和X射线单晶衍射等方式表征了配合物结构。晶体结构分析表明，每一个Mn（Ⅱ）被2个Qina分子螯合并通过Bpp配体桥联而形成一维线性结构；一维分子链通过分子链间的C-H…π及π…π作用构筑得配合物三维超分子结构。分别利用溴化乙锭荧光光谱法、琼脂糖凝胶电泳法研究了配合物对小牛胸腺DNA及质粒DNA的结合活性及切割活性。配合物表现出了一定的DNA结合力与切割活性。并利用MMT比色法，测试了配合物对Hela，MCF-7肿瘤细胞株的体外毒性，配合物表现出了一定的体外细胞毒性。 | |
| 关键词: 锰(Ⅱ) 配位聚合物 晶体结构 Hirshfeld表面分析 抗肿瘤活性 | |
| 基金项目: 国家自然科学基金（No.21763017），贵州省科学技术厅、六盘水市科学技术局、六盘水师范学院联合科技基金（黔科合J字LKLS[2013]20号，[2014]7450号），贵州省教育厅青年科技人才成长项目（黔教合KY字[2017]271号）资助。 | |
| Abstract: A coordination polymer of {[Mn(Qina)2(Bpp)]·2/3H2O}n (Qina=2-quinolinecarboxylic-carboxylate, Bpp=4,4'-trimethylenedipyridine) was synthesized and successfully obtained as single crystals. In the crystal, each Mn(Ⅱ) ion is chelated by two Qina groups, with each Bpp ligand bridging two Mn(Ⅱ) ions to form the 1D polymer chains. Furthermore, the 3D supramolecular architecture is directed by 1D-interchains via weak stacking interactions of C-H…π and π…π. The competition capacity of the complex about calf thymus DNA (ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complex to cleave the plasmid DNA (pBR322-DNA) was determined by gel electrophoresis assay. And the cytotoxic activity of complex was reviewed for two kinds of cancer cell lines (Hela, MCF-7), which results show that the coordination polymer has in vitro anti-tumor activity and cytotoxicity. | |
| Keywords: Mn(Ⅱ) coordination polymer crystal structure Hirshfeld surface analysis antitumor activity | |
| 投稿时间：2017-12-22 修订日期：2018-03-28 | |
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| 王仁舒,冯静,雷以柱,杨丹,朱明昌,邢家领,连明磊.生物活性配体喹啉-2-羧酸根锰(Ⅱ)配位聚合物的晶体结构及生物活性[J].无机化学学报,2018,34(7):1221-1230. | |
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