| 吡啶甲酸铬衍生物的合成、安全性及降糖活性 |
| Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives |
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| 摘要: 合成了4种新型吡啶甲酸铬衍生物并通过单晶衍射、电喷雾质谱、元素分析、电导率及红外光谱等手段对其结构进行了表征。通过循环伏安法研究了配体对配合物氧化还原活性的影响，通过Fenton-like反应观察了配合物诱发产生自由基的程度，发现其中有3个配合物诱发产生的自由基少于市售产品吡啶甲酸铬Cr（pic）3。动物活体实验表明，高剂量配合物3不会对小鼠脏器造成明显损伤，低剂量喂食能降低糖尿病小鼠的空腹血糖及低密度脂蛋白，其效果优于Cr（pic）3。 |
| 关键词: 吡啶甲酸铬 氧化还原性 安全性 降糖活性 |
| 基金项目: 国家自然科学基金（No.21271122，21571117）资助项目。 |
| Abstract: Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction, ESI-MS, analytical element, conductivity and IR analysis. The effect of substituent groups on its redox property and hydroxyl radical (·OH) generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction. As a result, three complexes generate less ·OH than Cr(pic)3. Besides, acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)3 in reducing fasten blood glucose (FBG) and low density lipoprotein by low dose. |
| Keywords: chromium picolinate redox property safety antihyperglycemic effects |
| 投稿时间：2018-04-07 修订日期：2018-06-21 |
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| 柴杰,杨斌盛,刘斌.吡啶甲酸铬衍生物的合成、安全性及降糖活性[J].无机化学学报,2018,34(10):1783-1791. |
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