| 由2-甲基-4-噻唑甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用 |
| Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid |
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| 摘要: 以2-甲基-4-噻唑甲酸（HMTZA，C5H5NO2S）为配体合成了3种新型过渡金属配合物[Co（MTZA）2（H2O）2]·3H2O（1），[Cu（MTZA）2（H2O）]·2H2O（2）和[Zn（MTZA）2（H2O）2]·3H2O（3）。对配合物进行了元素分析、红外光谱和热重分析表征，用单晶X射线衍射方法测定了配合物的晶体结构。结果表明，配合物1属于单斜晶系，空间群为P21/n，中心金属Co（Ⅱ）离子的配位数为6，配位构型为略为变形的八面体；配合物2属于三斜晶系，空间群为P1，Cu（Ⅱ）离子的配位构型是一个畸变的四方锥；配合物3属单斜晶系，空间群为P21/n，中心金属Zn（Ⅱ）离子的配位构型为畸变的八面体。用溴化乙锭荧光探针法测定了配体和配合物与DNA作用的荧光光谱，结果显示无论配体还是配合物均能使EB-DNA复合体系发生不同程度的荧光猝灭，且配合物的作用强度远大于配体。 |
| 关键词: 2-甲基-4-噻唑甲酸 过渡金属配合物 晶体结构 DNA作用 |
| 基金项目: 浙江省公益性技术应用研究计划项目（No.2014C32014）资助。 |
| Abstract: Three novel transition metal complexes[Co(MTZA)2(H2O)2]·3H2O (1),[Cu(MTZA)2(H2O)]·2H2O (2) and[Zn(MTZA)2(H2O)2]·3H2O (3) have been synthesized by using 2-methyl-4-thiazolecarboxylic acid (HMTZA,C5H5NO2S), structurally confirmed by single crystal X-ray diffraction method, and characterized by elemental analysis, IR analysis and TG. The single crystal X-ray diffraction reveals that complex 1 crystallizes in monoclinic system with space group P21/n. Central Co2+ is six-coordinated to constitute a slightly distorted octahedral structure. Complex 2 crystallizes in triclinic system with space group P1, and its coordination number is five, forming a slightly distorted pentahedral coordination geometry. Complex 3 crystallizes in monoclinic system with space group P21/n. Each Zn2+ is six-coordinated to constitute a distorted octahedral geometry. In addition, DNA-binding of the ligand and complexes were also studied by EtBr fluorescence probe. The interactions of complexes with DNA were stronger than the ligand. |
| Keywords: 2-methyl-4-thiazolecarboxylic acid transition metal complex crystal structure DNA-binding |
| 投稿时间：2018-06-05 修订日期：2018-09-28 |
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| 张敏芝,武大令,沈伟,赵国良.由2-甲基-4-噻唑甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用[J].无机化学学报,2018,34(12):2227-2237. |
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