基于Ni12P5纳米粒子的电化学传感器用于灵敏测定葡萄糖
Electrochemical Sensor Based on Ni12P5 Nanoparticles for Sensitive Determination of Glucose
作者单位E-mail
徐雯 黄山学院化学化工学院, 无机功能材料重点实验室, 黄山 245041  
周讯 黄山学院分析测试中心, 黄山 245041  
徐金明 黄山学院化学化工学院, 无机功能材料重点实验室, 黄山 245041  
徐涵 黄山学院化学化工学院, 无机功能材料重点实验室, 黄山 245041  
陶菲菲 绍兴文理学院化学化工学院, 绍兴 312000 feifeitao@usx.edu.cn 
摘要: 通过改进的热溶剂胶体合成法制备了单分散的Ni12P5纳米粒子,并利用X射线衍射、透射电子显微镜、X射线光电子能谱、X射线能谱对Ni12P5纳米粒子的晶体结构、化学组成和形貌等进行了表征。基于单分散Ni12P5纳米粒子研制出的非酶葡萄糖传感器具有出色的性能,其快速响应时间小于3 s,检测范围广(0.002~4.2 mmol·L-1),灵敏度高达1 572 mA·L·mol-1·cm-2,检测限低至0.8 μmol·L-1。此外,该传感器在用于人体血液中葡萄糖的实际检测中取得了满意的效果。
关键词: 纳米粒子  生物传感器  葡萄糖  电分析
基金项目: 安徽省教育厅自然科学研究项目(No.KJHS2017B06,KJ2018A0409)和浙江省科技厅项目(No.2017C33209)资助。
Abstract: A non-enzymatic glucose biosensor was designed for the first time based on the employment of monodisperse Ni12P5 nanoparticles (NPs), which were fabricated by a modified one-pot hot-solution colloidal preparation method. The crystal structure, chemical composition and morphology of the Ni12P5 NPs was determined by using power X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectra, X-ray energy dispersive spectrometer. The developed sensor has presented excellent performance which involved a quick response time less than 3 s, a broad detection ranging from 0.002 to 4.2 mmol·L-1, a high sensitivity up to 1 572 mA·L·mol-1·cm-2, and a detection limit as low as 0.8 μmol·L-1. Additionally, it can be used to detect the glucose in the human blood serum with satisfactory result.
Keywords: nanoparticles  biosensor  glucose  electroanalysis
投稿时间:2018-11-21 修订日期:2019-01-08
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徐雯,周讯,徐金明,徐涵,陶菲菲.基于Ni12P5纳米粒子的电化学传感器用于灵敏测定葡萄糖[J].无机化学学报,2019,35(4):729-736.
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