| 基于Ni12P5纳米粒子的电化学传感器用于灵敏测定葡萄糖 |
| Electrochemical Sensor Based on Ni12P5 Nanoparticles for Sensitive Determination of Glucose |
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| 摘要: 通过改进的热溶剂胶体合成法制备了单分散的Ni12P5纳米粒子，并利用X射线衍射、透射电子显微镜、X射线光电子能谱、X射线能谱对Ni12P5纳米粒子的晶体结构、化学组成和形貌等进行了表征。基于单分散Ni12P5纳米粒子研制出的非酶葡萄糖传感器具有出色的性能，其快速响应时间小于3 s，检测范围广（0.002~4.2 mmol·L-1），灵敏度高达1 572 mA·L·mol-1·cm-2，检测限低至0.8 μmol·L-1。此外，该传感器在用于人体血液中葡萄糖的实际检测中取得了满意的效果。 |
| 关键词: 纳米粒子 生物传感器 葡萄糖 电分析 |
| 基金项目: 安徽省教育厅自然科学研究项目（No.KJHS2017B06，KJ2018A0409）和浙江省科技厅项目（No.2017C33209）资助。 |
| Abstract: A non-enzymatic glucose biosensor was designed for the first time based on the employment of monodisperse Ni12P5 nanoparticles (NPs), which were fabricated by a modified one-pot hot-solution colloidal preparation method. The crystal structure, chemical composition and morphology of the Ni12P5 NPs was determined by using power X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectra, X-ray energy dispersive spectrometer. The developed sensor has presented excellent performance which involved a quick response time less than 3 s, a broad detection ranging from 0.002 to 4.2 mmol·L-1, a high sensitivity up to 1 572 mA·L·mol-1·cm-2, and a detection limit as low as 0.8 μmol·L-1. Additionally, it can be used to detect the glucose in the human blood serum with satisfactory result. |
| Keywords: nanoparticles biosensor glucose electroanalysis |
| 投稿时间：2018-11-21 修订日期：2019-01-08 |
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| 徐雯,周讯,徐金明,徐涵,陶菲菲.基于Ni12P5纳米粒子的电化学传感器用于灵敏测定葡萄糖[J].无机化学学报,2019,35(4):729-736. |
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