| 在纯水体系和活细胞中高选择检测Fe3+的香豆素荧光探针 | |
| A Highly Selective Coumarin-based Fluorescent Probe for Detecting Fe3+ in Pure Water Systems and Living Cells | |
| 摘要: 设计、合成了一种香豆素类荧光探针CF470，该探针通过引入高水溶性且选择性与Fe3+配位的多羟基基团实现了纯水体系中Fe3+的检测。当在探针体系中加入Fe3+后，其强烈的蓝色荧光在2 min内就可被完全猝灭。探针不仅对Fe3+快速、高选择响应，而且由于引入了亲水的多羟基基团具有良好的水溶性。更重要的是，探针对活细胞低毒、生物相容性好，被成功应用于活细胞中Fe3+的成像。 | |
| 关键词: 铁离子 香豆素 纯水体系 荧光成像 活细胞 | |
| 基金项目: 国家自然科学基金（No.21472148，21072158），陕西高等教育精品课程建设基金和西北大学优秀青年学术骨干支持计划资助项目 | |
| Abstract: A novel fluorescent probe CF470 was designed and synthesized, for detecting Fe3+ in pure water systems, composed of coumarin derivative as a fluorophore, and the trihydroxyl group as both the Fe3+-sensing site and hydrophilic group. Adding Fe3+ into the solution of CF470 rendered intense blue fluorescence quenching within 2 min. The probe showed excellent specificity, outstanding water-solubility in virtue of presence of the exceedingly hydrophilic trihydroxyl moiety, and fast response time. More importantly, the low cytotoxic and good biocompatible probe was also successfully utilized to image Fe3+ in living cells. | |
| Keywords: iron ions coumarin pure water systems fluorescent imaging living cells | |
| 投稿时间：2018-12-08 修订日期：2019-01-19 | |
| 摘要点击次数: 2485 | |
| 全文下载次数: 782 | |
| 刘琪梦,汪欢,郭昊冉,郭媛.在纯水体系和活细胞中高选择检测Fe3+的香豆素荧光探针[J].无机化学学报,2019,35(5):923-929. | |
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