| 5-氟尿嘧啶卟啉锰/锌配合物的合成、光电性质及抗癌活性 | |
| Syntheses, Spectral and Electrochemical Properties, Antitumor Activities of Manganese/Zinc Complexes with Porphyrin Modified by 5-Fluorouracil | |
| 摘要: 合成了新型5-氟尿嘧啶修饰的自由卟啉5-（2-（5-氟尿嘧啶-3-基）乙氧基苯基）-10，15，20-三苯基卟啉（L）及其锰配合物（MnL）和锌配合物（ZnL）。通过紫外-可见光谱、红外光谱、核磁共振氢谱及高分辨质谱等手段进行了结构表征。研究了它们的荧光性质和电化学性质；应用标准磺酰罗丹明B法（SRB法）测试了目标化合物对人肺癌细胞株A549、人肝癌细胞株Bel-7402和人结肠癌细胞株HCT-8生长的抑制活性。结果表明：相同实验条件下，不同金属离子对配合物的荧光强度存在较大影响：锌配合物具有荧光猝灭的性质，而锰配合物未能观察到明显的荧光发射光谱；与自由卟啉和锌配合物相比，锰配合物除卟啉环发生氧化还原反应外，Mn2+自身也发生了氧化还原反应；抗癌活性测试显示锰配合物较其他2种化合物有较好的抗癌活性。 | |
| 关键词: 金属卟啉 5-氟尿嘧啶 荧光 电化学性质 抗癌活性 | |
| 基金项目: 河北省自然科学基金（No.B2014408009）和河北省教育厅青年基金（No.QN2014117）资助项目。 | |
| Abstract: One novel free porphyrin modified with 5-fluorouracil (5-(2-(5-fluorouracil-3-yl)-ethoxyphenyl)-10,15,20-triphenyl porphyrin, L) and its manganese complex (MnL), zinc complex (ZnL) were synthesized. They were characterized by UV-Vis, IR, 1H NMR and MS. Their fluorescence properties and electrochemical properties were examined. The antitumor activities of them were evaluated by SRB assay in vitro against three human cancer cell lines. The results indicate that metal ions have a significant influence on the fluorescence intensity of complexes under the same experimental conditions:the fluorescence quenching was exhibited for zinc complex, but fluorescence signal had not been detected for manganese complex. The cyclic voltammetry of manganese complex was different from those of free porphyrin and zinc complex, which showed not only the redox of porphyrin ring but also the redox of Mn2+ ion. The biological tests revealed that manganese complex has a higher inhibitory rate than L and ZnL, but is less active than 5-fluorouracil. | |
| Keywords: metalloporphyrin 5-fluorouracil fluorescence electrochemical property antitumor activity | |
| 投稿时间：2018-10-25 修订日期：2019-03-13 | |
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| 任丽磊,彭晓霞,王树军,肖立伟,李泽强.5-氟尿嘧啶卟啉锰/锌配合物的合成、光电性质及抗癌活性[J].无机化学学报,2019,35(6):965-970. | |
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