| 由氟哌酸构筑的铜(Ⅱ)配合物的合成、结构和抑菌性能 |
| Synthesis, Crystal Structure, and Antibacterial Activity of Copper(Ⅱ) Complexes Based on Norfloxacin |
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| 摘要: 通过水热法合成了2种铜配合物[Cu2（HNOR）2Cl]n（1）和[Cu2Cl3]·H3NOR·H2O（2）（H2NOR=氟哌酸），并对其结构进行了X射线单晶衍射测定。结果表明，虽然反应物相同，但在酸度和碱度条件下分别生成具有不同结构的配合物。通过氢键和π-π相互作用，2种配合物形成了稳定的二维结构。同时，选择大肠杆菌和金黄色葡萄球菌作为革兰氏阳性和革兰氏阴性进行了抑菌活性实验。抑菌活性表明，2种配合物对大肠杆菌和金黄色葡萄球菌都有很好的抑制作用。 |
| 关键词: 氟哌酸 铜配合物 抑菌活性 二维结构 |
| 基金项目: 通化师范学院学生创新与技能训练项目（No.cs2019036）资助 |
| Abstract: Two copper complexes[Cu2(HNOR)2Cl]n (1) and[Cu2Cl3]·H3NOR·H2O (2) (H2NOR=norfloxacin) were prepared by hydrothermal process and their structures were determined by single-crystal X-ray diffraction. The results showed that although the reactants are the same, the complexes with different structures are formed under acidic and basic conditions. Through the hydrogen bonding interactions and π-π interactions, two complexes form stable two-dimensional structure. At the same time, Escherichia coli and Staphylococcus aureus were selected as Gram positive and Gram negative for antibacterial activity experiments. Bacteriostatic activity showed that both complexes had a good inhibitory effect on Escherichia coli and Staphylococcus aureus. |
| Keywords: norfloxacin copper complexes antibacterial activity two-dimensional structure |
| 投稿时间：2019-07-22 修订日期：2019-11-10 |
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| 黄艳菊,徐美玲,张俊.由氟哌酸构筑的铜(Ⅱ)配合物的合成、结构和抑菌性能[J].无机化学学报,2020,36(3):515-520. |
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