对氯苄基锡酰腙配合物的合成、抗肿瘤活性及其与DNA相互作用
Syntheses, Antitumor Activity and DNA Interaction of p-Chlorine-Benzyltin Complexes Based on Acylhydrazone Ligand
作者单位E-mail
樊善继 南华大学附属第一医院乳甲外科, 衡阳 421001 Firear333@hotmail.com 
徐家墀 南华大学附属第一医院乳甲外科, 衡阳 421001  
胡泽成 南华大学附属第一医院乳甲外科, 衡阳 421001  
崔莺 衡阳师范学院化学与材料科学学院, 衡阳 421008  
谭宇星 衡阳师范学院化学与材料科学学院, 衡阳 421008  
蒋伍玖 衡阳师范学院化学与材料科学学院, 衡阳 421008  
摘要: 用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1C2),通过元素分析、IR、1H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1C2的热稳定性以及配合物对癌细胞NCI-H460、HepG2、MCF7的体外抑制活性,发现配合物C2对癌细胞NCI-H460、HepG2、MCF7等均表现出良好的抑制作用。利用紫外吸收光谱、荧光猝灭光谱以及粘度法研究了配合物C2与ct-DNA之间的相互作用,结果表明配合物C2以插入模式与DNA结合。
关键词: 有机锡配合物  合成  晶体结构  抗肿瘤  DNA
基金项目: 湖南省自然科学基金(No.2020JJ8096)资助。
Abstract: Two p-chlorobenzyltin complexes have been synthesized via the reaction of p-methyl benzoyl hydrazidebenzoyl formic acid or benzoyl hydrazide-benzoyl formic acid with di-p-chlorobenzyltin dichloride. The complexes C1 and C2 have been characterized by IR, 1H NMR, 13C NMR, 119Sn NMR spectra, elemental analysis and HRMS, and the crystal structures have been determined by X-ray diffraction. The thermogravimetric of the complexes C1 and C2 were analyzed, and in vitro antitumor activities of both complexes were evaluated by MTT (3-(4,5-dimethyl-thiazole-2)-2,5-diphenyltetrazolium bromide) against three human cancer cell lines (NCI-H460, HepG2 and MCF7). It was found that complex C2 showed a good inhibitory effect on cancer cells NCI-H460, HepG2, MCF7. The interaction of complex C2 with DNA was investigated using electronic absorption spectroscopy, fluorescence quench, and viscosity measurement. It was found that the complex could bind to DNA through an intercalation mode.
Keywords: organotin complex  synthesis  crystal structure  antitumor activities  DNA
投稿时间:2020-10-29 修订日期:2020-12-15
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樊善继,徐家墀,胡泽成,崔莺,谭宇星,蒋伍玖.对氯苄基锡酰腙配合物的合成、抗肿瘤活性及其与DNA相互作用[J].无机化学学报,2021,37(4):684-692.
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