| 基于硝基咪唑衍生物的Cu（Ⅱ）、Ag（Ⅰ）配合物的合成、晶体结构及生物活性 |
| Synthesis,Crystal Structure and Biological Activity of Cu(Ⅱ) and Ag(Ⅰ) Complexes Involving Nitroimidazole Derivative |
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| 摘要: 设计、合成了硝基咪唑衍生物N，N'-二甲基-5-硝基-2，2'-联咪唑（L）的过渡金属配合物[Cu （L）（Ac）2]2（1）和[Ag （L）（NO3）]·H2O （2）。X射线单晶衍射分析表明配合物1是一个醋酸根桥联的五配位双核Cu（Ⅱ）浆轮笼型配合物。通过元素分析、紫外光谱、红外光谱、固体荧光光谱、电喷雾质谱、摩尔电导率及热重分析等测试手段对配合物2进行了性质表征，初步确定了其结构可能为二配位的线型单核配合物。紫外可见光谱、荧光光谱及黏度法分析表明配合物1与小牛胸腺DNA （ct-DNA）相互作用强于配体及配合物2。以2倍稀释法研究了配体L及配合物的抗厌氧菌活性，发现配体对伴放线放线杆菌（ATCC 29523）的抑菌活性最强（最低抑菌浓度MIC=0.625~1.25 μg·mL-1），这甚至要强于经典抗厌氧菌药物甲硝唑的抗菌性。 |
| 关键词: 硝基咪唑衍生物 金属配合物 晶体结构 与DNA相互作用 抗厌氧菌活性 |
| 基金项目: 陕西省科技厅自然科学基金（No.2020JM-614）、陕西省教育厅产业化项目（No.2019JQ068）和陕西省科技厅社发项目（No.2021SF-323）资助。 |
| Abstract: The copper(Ⅱ) and silver(I) complexes[Cu(L)(Ac)2]2 (1),[Ag(L)(NO3)]·H2O (2) (L=N,N'-dimethyl-5-nitro-2, 2'-biimidazole) has been synthesized. X-ray crystallographic study was used to determine the crystallographic structure of complex 1, which exhibits a five-coordinated dimeric copper-acetato paddle-wheel geometry. Complex 2 was characterized by elemental analysis, UV-Vis, FT-IR, solid fluorescence spectra, thermogravimetric analysis, ESI-MS and conductivity analysis. The structure of complex 2 probably was a two-coordinated mononuclear structural unit of linear configuration. The binding property of L and complexes toward calf thymus DNA (ct-DNA) was figured out via electronic absorption, fluorescence spectra and viscosity measurements. Complex 1 revealed slightly stronger DNA binding capability than 2 and ligand. The antianaerobe activities of L and its complexes were tested by two-fold agar dilution method. The results showed that L displayed favorable activity of anti-anaerobic bacteria against Actinobacillus actinomycetem (ATCC 29523) selectively with minimum inhibitory concentrations of 0.625~1.25 μg·mL-1, even better than the classical anti-anaerobic drug metronidazole. |
| Keywords: nitroimidazole derivative metal complex crystal structure DNA interaction anti-anaerobic activity |
| 投稿时间：2021-01-27 修订日期：2021-05-25 |
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| 杨莉宁,刘春叶,成昭,梁玲玲,张剑.基于硝基咪唑衍生物的Cu（Ⅱ）、Ag（Ⅰ）配合物的合成、晶体结构及生物活性[J].无机化学学报,2021,37(9):1547-1554. |
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