肿瘤靶向Pt-Cu基纳米平台用于近红外二区光声成像引导的光热治疗
Tumor-Targeted Pt-Cu Nanoplatform for Photothermal Therapy Guided by the Second Near-Infrared Window Photoacoustic Imaging
作者单位E-mail
郑子良 山西医科大学第三医院, 山西白求恩医院, 山西医学科学院, 太原 030032  
曲波涛 山西医科大学第三医院, 山西白求恩医院, 山西医学科学院, 太原 030032  
杨晓荣 山西医科大学第三医院, 山西白求恩医院, 山西医学科学院, 太原 030032  
刘玲 山西医科大学第三医院, 山西白求恩医院, 山西医学科学院, 太原 030032  
张瑞平 山西医科大学第三医院, 山西白求恩医院, 山西医学科学院, 太原 030032 zrp_7142@sxmu.edu.cn 
摘要: 基于层层(LBL)自组装技术,在Pt-Cu纳米合金表面依次包覆带正电的聚赖氨酸(PLL)和带负电的透明质酸(HA),成功构筑Pt-Cu@PLL@HA纳米平台。HA不仅延长了纳米平台血液循环时间,还可实现肿瘤主动靶向作用,提升肿瘤部位富集效果。在肿瘤区域透明质酸酶(HAase)作用下HA快速降解,释放Pt-Cu@PLL (+)颗粒,有利于肿瘤细胞特异性摄取。基于Pt-Cu合金良好的近红外二区(NIR-Ⅱ)吸收性能,实现了NIR-Ⅱ光声成像引导的NIR-Ⅱ光热高效抗肿瘤效果。
关键词: 近红外二区  光热治疗  光声成像  Pt-Cu合金  层层自组装
基金项目: 国家自然科学基金(No.81571747,81771907)和山西省面上青年基金(No.201901D211343)资助。
Abstract: A nanoplatform Pt-Cu@PLL@HA based on PtCu nano-alloys encapsulated in the positively charged polylysine (PLL) and negatively charged hyaluronic acid (HA) was constructed via layer-by-layer (LBL) self-assem-bly technology. HA not only prolonged the blood circulation time of Pt-Cu@PLL@HA, but also realized the active tumor targeting and enhanced its high accumulation in tumor region. After fast HA degradation in response to hyaluronidase (HAase) in the tumor microenvironment, the site-specific exposure of Pt-Cu@PLL(+) was conducive to the uptake of tumor cells. Owing to the strong NIR-Ⅱ (the second near-infrared window) absorption capability of Pt-Cu alloy, the effective photothermal tumor ablation could be realized by the precise guidance of NIR-Ⅱ photoacoustic imaging.
Keywords: the second near-infrared window  photothermal therapy  photoacoustic imaging  Pt-Cu alloy  layer-by-layer self-assembly
投稿时间:2021-04-18 修订日期:2021-09-02
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郑子良,曲波涛,杨晓荣,刘玲,张瑞平.肿瘤靶向Pt-Cu基纳米平台用于近红外二区光声成像引导的光热治疗[J].无机化学学报,2021,37(11):1991-2001.
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