| 两个锰配合物的合成、晶体结构及与DNA的作用 |
| Syntheses, Crystal Structures and DNA-Binding of Two Manganese Complexes |
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| 摘要: 用常规溶液法由氯化锰（MnCl2·4H2O）和4-甲基-1，2，3-噻二唑-5-甲酸（HL）反应制备了配位聚合物[Mn3（L）6（H2O）4]n（1），加入配体菲咯啉（phen）后合成了配合物[Mn2（phen）4（H2O）2Cl2]（L）2·3H2O（2）。用元素分析、红外光谱、热重分析及单晶X射线衍射进行了配合物的表征。单晶结构分析表明：配合物1属单斜晶系P21/c空间群，3个锰离子通过6个L-中的氧原子双齿桥联，形成了线型三核簇合物单元，簇合物单元间又通过其中一个噻二唑环上的氮原子与另一个簇合物单元的锰原子配位，形成层状结构；配合物2属三斜晶系P1空间群，锰离子分别与1个氯离子、1个水分子和2个phen分子中的4个氮原子配位，形成六配位的扭曲八面体阳离子，与之电荷平衡的是L-。用溴化乙锭荧光光谱法研究了HL和配合物与DNA作用情况，结果表明配合物与DNA的作用强于HL，有平面型配体的配合物2的作用又强于配合物1。 |
| 关键词: 4-甲基-1，2，3-噻二唑-5-甲酸 锰 配合物 晶体结构 DNA作用 |
| 基金项目: 浙江省公益性技术应用研究计划项目（No.2014C32014）资助 |
| Abstract: Coordination polymer[Mn3(L)6(H2O)4]n (1) was prepared by the reaction of manganese chloride (MnCl2·4H2O) and 4-methyl-1, 2, 3-thiadiazole-5-carboxylic acid (HL) by conventional solution method, and complex[Mn2(phen)4(H2O)2Cl2](L)2·3H2O (2) was synthesized after adding the ligand 1,10-phenanthroline (phen). The complexes were characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, and singlecrystal X-ray diffraction. The single-crystal structure analysis shows that complex 1 belongs to the monoclinic system, P21/c space group. The three manganese ions are bridged in bidentate fashion by the oxygen atoms in the six thiadiazole formate groups to form a linear trinuclear molecule cluster compound. The cluster unit is connected by the coordination of nitrogen atom from one of the thiadiazole rings and the manganese atom of the other cluster unit to form a layered structure. Complex 2 belongs to the triclinic crystal system, P1 space group. The central metal manganese ion coordinated with four nitrogen atoms from two phen molecules, one chloride anion, and one oxygen atom of coordination water molecule respectively, forming a six-coordinated twisted octahedral structure cation. The thiadiazole formate anion plays the role of charge balance. Ethidium bromide fluorescence spectrometry was used to determine the interaction between HL and complexes with DNA, respectively. The results showed that the interaction between the complexes and DNA was stronger than that of HL, and complex 2 with a planar ligand had a stronger effect than that of complex 1. |
| Keywords: 4-methyl-1,2,3-thiadiazol-5-carboxylic acid manganese complex crystal structure DNA-binding |
| 投稿时间：2021-08-02 修订日期：2021-12-18 |
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| 徐蕴泽,沈金杯,赵国良,胡未极.两个锰配合物的合成、晶体结构及与DNA的作用[J].无机化学学报,2022,38(2):285-294. |
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