| 喹啉-2-甲醛缩4-氟苯基氨基硫脲Cd（Ⅱ）/Fe（Ⅲ）配合物的合成、晶体结构和DNA结合性质 |
| Synthesis, Crystal Structures, and DNA-Binding Properties of Cd(Ⅱ)/Fe(Ⅲ) Complexes with 4-Fluorophenyl-N-(quinolin-2-ylmethylene) thiosemicarbazide |
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| 摘要: 合成并通过单晶衍射、元素分析、红外光谱表征了配合物[Cd2（L）2（NO3）2]（1）、[Fe （L）2]NO3·3CH3OH （2）和配体硝酸盐（H2L） NO3（HL=喹啉-2-甲醛缩4-氟苯基氨基硫脲）。单晶衍射结果表明，双核配合物1中，每个Cd（Ⅱ）离子与一个N2S供体L-、一个双齿配位的硝酸根和相邻缩氨基硫脲配体的μ2-桥联S原子配位，采取扭曲的八面体配位构型。配合物2中，Fe（Ⅲ）离子与来自2个三齿配体L-的4个N原子和2个S原子配位，同样采取扭曲的八面体配位构型。荧光光谱、紫外光谱以及粘度实验结果表明，配合物2与ct-DNA的结合模式为插入的结合方式，而配体HL和配合物1与ct-DNA以沟面结合的方式相互作用，且配合物2与ct-DNA的结合能力优于配体和配合物1。另外，细胞毒理实验结果表明3种化合物中配合物2具有最强的抑制HeLa肿瘤细胞增殖能力。 |
| 关键词: 喹啉 缩氨基硫脲 配合物 晶体结构 DNA相互作用 |
| 基金项目: 国家自然科学基金（No.21907023，21001040）、河南省科技厅科技攻关项目（No.212102210033）和河南省教育厅自然科学基金（No.19A150001）资助。 |
| Abstract: Two complexes[Cd2(L)2(NO3)2] (1) and [Fe(L)2]NO3·3CH3OH (2), as well as (H2L)NO3 (HL=4-fluorophenyl-N-(quinolin-2-ylmethylene)thiosemicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction, elemental analysis, and IR. The results show that 1 is a centrosymmetry binuclear complex, in which each central Cd(Ⅱ) ion is coordinated by one independent anionic ligand L- with a[N2S] donor set, one bidentate nitrate anion, and another μ2-bridged S atom from the adjacent thiosemicarbazone, thus providing a distorted octahedron geometry. The Fe(Ⅲ) ion in complex 2 displays the same coordination geometry as the Cd (Ⅱ) ion in 1, while is surrounded by two tridentate L- ligands. The fluorescence spectra, the absorption spectra, and the viscosity measurements indicate that complex 2 could effectively bind with ct-DNA through intercalation mode, while HL and complex 1 might interact with ct-DNA by outside groove binding mode, and the binding affinity of complex 2 with ct-DNA was stronger than those of HL and complex 1. In addition, the results of cytotoxicity experiments showed that complex 2 had the strongest ability to inhibit the proliferation of HeLa tumor cells among the three compounds. |
| Keywords: quinoline thiosemicarbazone complex crystal structure DNA interaction |
| 投稿时间：2021-07-12 修订日期：2022-07-18 |
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| 李晓红,吴现为,王元,吴伟娜.喹啉-2-甲醛缩4-氟苯基氨基硫脲Cd（Ⅱ）/Fe（Ⅲ）配合物的合成、晶体结构和DNA结合性质[J].无机化学学报,2022,38(9):1790-1798. |
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| Support information: 相关附件： 210327_Supplementary_Material.docx |
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