| 一种带吡啶悬臂大环异双核Zn（Ⅱ）-Ni（Ⅱ）配合物的合成、晶体结构及其DNA结合/切割性质 | |
| Synthesis, Crystal Structure, and DNA Binding/Cleavage Properties of a Macrocyclic Heterobinuclear Zn(Ⅱ)-Ni(Ⅱ) Complex with Pyridylmethyl Pendant-Arms | |
| 摘要: 合成了一种带吡啶悬臂的不对称大环异双核金属Zn（Ⅱ）-Ni（Ⅱ）配合物[ZnNi （L）]（ClO4）2·H2O （H2L=3，3'-（（ethane-1，2-diylbis （（pyridin-2-ylmethyl） azanediyl）） bis （methyl ene）） bis （2-hydroxy-5-methylbenzaldehyde）），通过红外光谱、电喷雾质谱、单晶X射线衍射对其结构进行了表征。结果表明Zn（Ⅱ）和Ni（Ⅱ）的配位环境分别为扭曲的三角锥和正四面体。利用紫外光谱、粘度实验和循环伏安法对该配合物与DNA的相互作用模式进行了研究，结果表明配合物与小牛胸腺DNA （CT-DNA）的结合方式为插入模式，其相应的结合常数Kb=1.05×105 L·mol-1。另外，该配合物对pBR322 DNA有一定的切割作用。 | |
| 关键词: 悬臂大环配合物 晶体结构 配位环境 DNA结合 DNA切割 | |
| 基金项目: 湖北省重点研发项目（No.2020BBB068）和湖北省自然基金（No.2020CFB400）资助。 | |
| Abstract: A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn (Ⅱ)-Ni(Ⅱ) complex[ZnNi(L)](ClO4)2·H2O (H2L=3,3'-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene)) bis(2-hydroxy-5-methylbenzaldehyde)) has been obtained and characterized by spectroscopy, elemental analysis and single-crystal X-ray diffraction. The coordination environment of Zn(Ⅱ) and Ni(Ⅱ) can be described as approximately distorted triangular prism and square pyramid, respectively. The Zn-Ni distance bridged by two phenoxide groups is 0.303 63(6) nm. The interaction between the complex and calf thymus DNA (CT-DNA) has been further confirmed by UV-Vis spectrophotometry, viscosity, and cyclic voltammetry study. The complex showed a good binding property to CT-DNA with a binding constant of 1.05×105 L·mol-1. The DNA cleavage activity has also been investigated using agarose gel electrophoresis. | |
| Keywords: pendant-armed macrocyclic complex crystal structure coordination environment DNA binding DNA cleavage | |
| 投稿时间：2022-03-21 修订日期：2022-08-01 | |
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| 丁佩佩,李铭,吴宇,闫俊涛,王春蕾,王洋,毛佳伟.一种带吡啶悬臂大环异双核Zn（Ⅱ）-Ni（Ⅱ）配合物的合成、晶体结构及其DNA结合/切割性质[J].无机化学学报,2022,38(9):1853-1861. | |
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| Support information: 相关附件： 220123_Supporting_information.docx | |
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