| 含有席夫碱配体的钌配合物的合成、表征及抗肿瘤活性 |
| Synthesis, Characterization, and Antitumor Activity of Ruthenium(Ⅱ) Complexes Based on Schiff Base Ligand |
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| 摘要: 设计并合成了3个含有席夫碱基团的配体（BLn，n=1~3）及相应的双核联吡啶钌配合物[Ru （BLn）（bpy）2]2（ClO4）4，其中bpy=2，2'-联吡啶，BLn=（（PyCHN）-Ph-O-C6H4）2R （PyCHN=N-2-吡啶亚甲基，R=none （Ru1），—C （CH3）2（Ru2），—SO2（Ru3））。通过元素分析、核磁氢谱、红外光谱、质谱等方法对配体和配合物进行了表征。通过体外细胞毒性实验研究了Ru1~Ru3对宫颈癌细胞（Hela）、胃癌细胞（BGC823）、胃癌细胞（SGC-7901）三种肿瘤细胞和人正常胚肺成纤维细胞MRC-5的细胞毒性，实验结果表明Ru3的抗肿瘤活性最好，而Ru1~Ru3均对BGC823具有选择性。 |
| 关键词: 席夫碱配体 双核钌配合物 细胞毒性 |
| 基金项目: 山西省高等学校科技创新项目（No.2020L0334）资助 |
| Abstract: A series of new Schiff base ligands (BLn, n=1-3) and complexes have been synthesized. Binuclear ruthenium complexes[Ru(BLn)(bpy)2]2(ClO4)4, where bpy=2, 2'-bipyridine, BLn=((PyCHN)-Ph-O-C6H4) 2R (PyCHN=N-2-pyridylmethylene, R=none for Ru1,-C(CH3)2 for Ru2 and-SO2 for Ru3), have been prepared and characterized by element analysis, 1H NMR, IR, and mass spectrometry methods. The cytotoxicity to cervical cancer cells (Hela), gastric cancer cells (BGC823), gastric cancer cells (SGC-7901), and human normal embryonic lung fibroblasts cells (MRC-5) of the three complexes in vitro was evaluated using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. It is worth noting that Ru1-Ru3 showed excellent antitumor effects in a cellular study for BGC823 in vitro. However, Ru3 exhibited the highest cytotoxicity to any cancer cells than Ru1 and Ru2. |
| Keywords: Schiff base ligand binuclear ruthenium complexes cytotoxicity |
| 投稿时间：2021-11-25 修订日期：2022-06-06 |
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| 贾士芳,郝秀丽,温艳珍,张燕.含有席夫碱配体的钌配合物的合成、表征及抗肿瘤活性[J].无机化学学报,2022,38(10):1919-1926. |
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