| 一种席夫碱Al3+荧光探针的制备及细胞成像应用 |
| A Schiff Base Fluorescent Probe for Al3+: Synthesis and Application in Living Cells Imaging |
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| 摘要: 以4-（二乙氨基）水杨醛与奥肼缩合制备了一例席夫碱类荧光探针1，通过1H NMR、13C NMR和电喷雾电离质谱表征了1的结构。光谱分析实验结果显示，探针1可选择性与Al3+作用，在495 nm处荧光发射峰显著增强。探针对Al3+的检测灵敏度高，检测限低至1.44 μmol·L-1。结合理论计算，证实探针以三齿配位的模式，与Al3+形成1∶1型稳定配合物。此外，该探针还可用于活细胞中Al3+的检测。 |
| 关键词: 荧光探针 细胞成像 席夫碱 Al3+ |
| 基金项目: 国家自然科学基金（No.21907023，21001040）、江西省大学生创新训练计划项目（No.S202111318057）和河南理工大学研究生教改项目（No.2021YJ16）资助 |
| Abstract: A fluorescent probe 1 has been synthesized by the Schiff base condensation of 4-(diethylamino)salicylaldehyde with oxamic hydrazide, which has been carefully characterized through 1H NMR, 13C NMR, and electrospray ionization mass spectrometer. Probe 1 exhibited a quite weak emission at 495 nm, which could selectively and sensitively recognize Al3+ from other cations by a notable fluorescence enhancement. The limit of detection of probe 1 for Al3+ was as low as 1.44 μmol·L-1, indicating its high sensitivity. Based on theory calculation results, probe 1 is proposed to coordinate with Al with the ratio of 1:1 in a tridentate mode. Moreover, the probe was applied to imaging Al3+ in living cells. |
| Keywords: fluorescent probe cell imaging Schiff base Al3+ |
| 投稿时间：2022-03-08 修订日期：2022-08-03 |
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| 陈曦,李思媛,王元,吴伟娜,陈忠.一种席夫碱Al3+荧光探针的制备及细胞成像应用[J].无机化学学报,2022,38(10):1993-1998. |
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