| 铒掺杂羟基磷灰石的荧光及其生物矿化性能 |
| Fluorescence and Biomineralization Ability of Erbium-Doped Hydroxyapatite |
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| 摘要: 通过共沉淀法制备铒掺杂羟基磷灰石（Er-HAP）颗粒，应用Materials Studio模拟与X射线衍射、扫描电镜-能量色散谱、X射线光电子能谱和荧光光谱分析对其晶体结构、表面化学成分及其荧光性能进行表征。结果表明，离子半径稍小的Er3+会竞争性占据HAP晶格中一个Ca2+位点，在340 nm波长激发下，Er-HAP颗粒能在419 nm（紫色）、458 nm（蓝色）、501 nm（绿色）和535 nm（绿色）处发出很强的特征荧光，光致发光显示的4个发光带相应归属于4F3/2→4I15/2、4F5/2→4I15/2、4F7/2→4I15/2和4S3/2→4I15/2过渡态。相比掺杂量（物质的量分数）1% 的Er-HAP，掺杂量9% 的Er-HAP颗粒表面矿化速度和成骨性能均明显下降，即当Er掺杂量在约1% 时，其Er-HAP生物矿化能力相对较强。 |
| 关键词: 铒掺杂羟基磷灰石 生物矿化 光致发光 |
| 基金项目: 国家自然科学基金（No.51464037）、内蒙古自然科学基金（No.2021LHMS05023，2017MS（LH）0525）、内蒙古自治区研究生创新项目（No.SZ2020044）资助 |
| Abstract: Erbium-doped hydroxyapatite (Er-HAP) particles were prepared by the co-precipitation method. The crystal structure, surface chemical composition, and fluorescent properties of Er-HAP particles were characterized by the methods of X-ray diffraction combined with Materials Studio, scanning electron microscopy-energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. The results showed that Er3+ can competitively substitute for a Ca2+ site in the crystal lattice. Under the excitation of a 340 nm light source, Er-HAP particles emitted significant fluorescence at around 419 nm (purple), 458 nm (blue), 501 nm (green), and 535 nm (green), respectively. The four corresponding luminescence bands are attributed to 4F3/2 → 4I15/2, 4F5/2 → 4I15/2, 4F7/2 →4I15/2, and 4S3/2 → 4I15/2 transition states, respectively. Further, we evaluated the biomineralization ability by analyzing the formation of an interfacial layer after Er-HAP particles were immersed in simulated body fluid. When the dopant content (molar fraction) of Er3+ was 1%, it was observed that Er-HAP particles could form the mineralized layer with plate-like structures, and Er3+ incorporation affected the biomineralization ability, whereas the biomineralization rate and osteogenic performance significantly decreased with the increasing of the dopant content of Er3+. Therefore, the stronger biomineralization ability of Er-HAP particles might be exhibited while the Er dopant content was about 1%. |
| Keywords: Er3+ doped hydroxyapatite biomineralization photoluminescence |
| 投稿时间：2022-03-21 修订日期：2022-09-05 |
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| 白春华,侯欢健,杨小宁,李光辉.铒掺杂羟基磷灰石的荧光及其生物矿化性能[J].无机化学学报,2022,38(11):2154-2164. |
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