| 基于双靶向黑色素纳米粒的肿瘤深穿透光声成像 |
| Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle |
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| 摘要: 通过1-(3-二甲基氨基丙基)-3-乙基碳二亚胺和N-羟基丁二酰亚胺反应将透明质酸(hyaluronic acid，HA)和4-羧丁基三苯基溴化膦((4-carboxybutyl) triphenylphosphonium bromide，TPP)分子连接到聚乙二醇-氨基(PEG-NH2)修饰过的黑色素纳米颗粒(melanin nanoparticles，MNP)表面，设计合成了一种具有双靶向能力的黑色素纳米颗粒(MNP-TPP-HA)，赋予了黑色素的双靶向能力。体外三维(3D)多细胞肿瘤球荧光成像和活体肿瘤光声成像实验表明MNP-TPP-HA具有优异的肿瘤靶向穿透能力。 |
| 关键词: 双靶向 黑色素 光声成像 穿透能力 |
| 基金项目: 国家自然科学基金（No.82120108016，82071987）和国家万人计划项目（No.SQ2022RA2A300118）资助。 |
| Abstract: A dual-targeting melanin nanoparticle (MNP-TPP-HA) was constructed by grafting the carboxyl groups of hyaluronic acid (HA) and (4carboxybutyl) triphenylphosphonium bromide (TPP) onto the surface of polyethylene glycol-amino (PEG-NH2) modified MNP based on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS) reaction, endowing melanin with the ability of dual active targeting. The fluorescence imaging of in vitro three-dimensional (3D) tumor models and in vivo photoacoustic imaging (PAI) all reveal the excellent target penetration ability of MNP-TPP-HA. |
| Keywords: dual-targeting melanin photoacoustic imaging penetration ability |
| 投稿时间：2023-11-01 修订日期：2024-03-06 |
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| 曲波涛,王倩,宁晓刚,周雨欣,张瑞平.基于双靶向黑色素纳米粒的肿瘤深穿透光声成像[J].无机化学学报,2024,40(5):1025-1032. |
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