一例由多齿席夫碱构筑的Tb2配合物的结构、荧光性质及生物活性
A Tb2 complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity
作者单位E-mail
马鑫 太原师范学院化学与材料学院, 晋中 030619  
孙娅 太原师范学院化学与材料学院, 晋中 030619  
孙楠 太原师范学院化学与材料学院, 晋中 030619  
康倩 太原师范学院化学与材料学院, 晋中 030619  
张佳佳 太原师范学院化学与材料学院, 晋中 030619  
朱瑞涛 太原师范学院化学与材料学院, 晋中 030619  
高晓丽 太原师范学院化学与材料学院, 晋中 030619 gaoxl@tynu.edu.cn 
摘要: 使用多齿希夫碱配体 H4L(H4L=N',N″-((1E,1'E)-(1,10-菲咯啉-2,9-二酰基)双(亚甲基)双(2-羟基苯甲酰肼))与 Tb(acac)3·2H2O反应(acac-=乙酰丙酮根),通过溶剂热法,设计并合成了一例结构新颖的双核铽配合物[Tb2(L)(H2L)]·2CH3OH·CH3CN (1),并研究了该配合物的结构、荧光性质及生物活性。单晶X射线衍射分析表明该配合物主要含有2个TbⅢ离子和2个失去不同质子的配体离子(L4-和H2L2-)。中心Tb1和Tb2离子都是九配位的,其几何构型呈现扭曲的呼啦圈形。固体荧光实验测试结果表明:该配合物在室温下表现出Tb离子的荧光特征发射峰。生物活性研究表明,与配体H4L和稀土离子相比较,配合物具有更强的抗菌活性。采用紫外可见光谱法、循环伏安法、凝胶电泳法和荧光光谱法研究了该配合物与小牛胸腺DNA之间的相互作用,结果表明配合物主要以插入作用的方式与小牛胸腺DNA结合。
关键词: Tb2配合物  生物活性  DNA作用  荧光性质  晶体结构
基金项目: 国家自然科学基金(No.21671124)和山西省自然科学基金(No.20210302123324)资助。
Abstract: A new lanthanide binuclear Tb(III)-based complex with the formula [Tb2(L)(H2L)]·2CH3OH·CH3CN (1) have been synthesized via the solvothermal method by using a polydentate Schiff base ligand (H4L=N',N″-((1E,1'E)-(1,10 -phenanthroline-2,9-diyl) bis (methaneylylidene)) bis (2-hydroxybenzohydrazide)) reacting with Tb(acac)3·2H2O (acac-=acetylacetonate). It was characterized by IR, elemental analysis, single-crystal and powder X-ray diffraction. Single-crystal X-ray structure analysis reveals that complex 1 belongs to the triclinic system with $P \overline{1}$ space group, and the asymmetric unit mainly includes two Tb ions and two different deprotonated ligands (L4- and H2L2-). Both centre Tb1 and Tb2 ions are nine-coordinated with a [N4O5] coordination environment. The coordination geometry is shown as a distorted hula-hoop. In addition, the biological activity study shows that the complex has stronger antibacterial activity than H4L and Tb(acac)3·2H2O. The interaction between 1 and DNA was studied by UV-Vis spectroscopy, cyclic voltammetry, gel electrophoresis, and fluorescence spectroscopy. The results reveal that 1 could bind to calf thymus DNA mainly by intercalation. Ethidium bromide (EB) displacement experiments indicated that Stern-Volmer quenching constants of complexes 1 and H4L were 1.04 and 0.30, respectively.
Keywords: Tb2 complex  biological activity  DNA action  fluorescence property  crystal structure
投稿时间:2023-09-27 修订日期:2024-05-12
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马鑫,孙娅,孙楠,康倩,张佳佳,朱瑞涛,高晓丽.一例由多齿席夫碱构筑的Tb2配合物的结构、荧光性质及生物活性[J].无机化学学报,2024,40(7):1347-1356.
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