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Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate
Author NameAffiliationE-mail
ZHANG Fu-Xing Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China zfx8056@163.com 
HE Tang-Feng Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
YAO Shu-Fen Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
ZHU Xiao-Ming Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
SHENG Liang-Bing Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
KUANG Dai-Zhi Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
FENG Yong-Lan Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
YU Jiang-Xi Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
JIANG Wu-Jiu Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China  
Abstract: Di(p-chlorobenzy)tin 2-hydroxybenzoate with ladder-like framework[(μ3-O)(μ2-OH)(p-Cl-C6H4CH2Sn)2(O2CC6H4-OH-o)]2 (1) and triphenyltin 4-hydroxybenzoate (2) have been synthesized. The complexes were chara-cterized by elemental analysis, IR spectroscopy, thermogravimetric analysis and single-crystal X-ray diffraction. Quantum chemical ab initio calculation as well as in vitro anticancer activity test have been carried out for the complexes. The results showed that complex 1 forms a structure containing Sn2O2 ladder-like skeleton and the complex 2 forms a nuclear tin structure. The tin atoms in the complexes all are five-coordinated with distorted trigonal bipyramid geometry. The antitumor activity showed that complexes 1 and 2 have higher activities than cisplatin to HT-29, HepG2, MCF-7, Hela and A549 cell line in vitro. Their thermal stabilities were further investigated, and the results showed that complexes 1 and 2 were stable below 90℃ and below 120℃, respectively.
Keywords: organotin hydroxybenzoates  crystal structure  quantum chemistry  in vitro antitumor activity
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ZHANG Fu-Xing,HE Tang-Feng,YAO Shu-Fen,ZHU Xiao-Ming,SHENG Liang-Bing,KUANG Dai-Zhi,FENG Yong-Lan,YU Jiang-Xi,JIANG Wu-Jiu.Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate[J].Chinese Journal of Inorganic Chemistry,2019,35(4):598-604.
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Chinese Journal of Inorganic Chemistry