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Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate |
Author Name | Affiliation | E-mail | ZHANG Fu-Xing | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | zfx8056@163.com | HE Tang-Feng | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | YAO Shu-Fen | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | ZHU Xiao-Ming | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | SHENG Liang-Bing | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | KUANG Dai-Zhi | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | FENG Yong-Lan | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | YU Jiang-Xi | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | | JIANG Wu-Jiu | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Human 421008, China | |
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Abstract: Di(p-chlorobenzy)tin 2-hydroxybenzoate with ladder-like framework[(μ3-O)(μ2-OH)(p-Cl-C6H4CH2Sn)2(O2CC6H4-OH-o)]2 (1) and triphenyltin 4-hydroxybenzoate (2) have been synthesized. The complexes were chara-cterized by elemental analysis, IR spectroscopy, thermogravimetric analysis and single-crystal X-ray diffraction. Quantum chemical ab initio calculation as well as in vitro anticancer activity test have been carried out for the complexes. The results showed that complex 1 forms a structure containing Sn2O2 ladder-like skeleton and the complex 2 forms a nuclear tin structure. The tin atoms in the complexes all are five-coordinated with distorted trigonal bipyramid geometry. The antitumor activity showed that complexes 1 and 2 have higher activities than cisplatin to HT-29, HepG2, MCF-7, Hela and A549 cell line in vitro. Their thermal stabilities were further investigated, and the results showed that complexes 1 and 2 were stable below 90℃ and below 120℃, respectively. |
Keywords: organotin hydroxybenzoates crystal structure quantum chemistry in vitro antitumor activity |
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ZHANG Fu-Xing,HE Tang-Feng,YAO Shu-Fen,ZHU Xiao-Ming,SHENG Liang-Bing,KUANG Dai-Zhi,FENG Yong-Lan,YU Jiang-Xi,JIANG Wu-Jiu.Syntheses, Crystal Structures and in Vitro Antitumor Activity of Two Organotin Hydroxybenzoate[J].Chinese Journal of Inorganic Chemistry,2019,35(4):598-604. |
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