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A Visible BODIPY Probe for ‘Naked-Eye’ Detection of pH Value and Intracellular Fe3+
Author NameAffiliationE-mail
QU Xing-Yu Department of Chemistry and Chemical Engineering, Jinzhong University, Jinzhong, Shanxi 030619, China  
BIAN Yong-Jun Department of Chemistry and Chemical Engineering, Jinzhong University, Jinzhong, Shanxi 030619, China zshen@nju.edu.cn 
BAI Yang Department of Chemistry and Chemical Engineering, Jinzhong University, Jinzhong, Shanxi 030619, China  
SHEN Zhen School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
 		yjbian2013@jzxy.edu.cn 
Abstract: A fluorescence probe 2 containing 4-hydroxystyryl at the 3-position on the boron fluoride dipyrromethene(BODIPY) fluorophore was successfully synthesized in high yield using the 4-formylphenyl picolinate as the starting material instead of 4-hydroxybenzaldehyde. Probe 2 exhibits excellent optical performance, including good solubility, high extinction coefficient and high fluorescence quantum yield (Ф=0.90 in CH3OH). The absorption and emission bands of probe 2 are centered at 570 and 585 nm in CH3OH, respectively. When the pH value of the solution changes from acidity to basicity, both positive fluorescence response and visual color change make naked-eye detection of pH value possible due to the deprotonation of hydroxyl group. With the addition of Fe3+ ions into the solution, visual color changes and blue shift of the absorption and fluorescence peak were detected as well. Hence, the probe 2 could also be used as a ratiometric fluorescent probe for selectively monitoring Fe3+ ion in solution and in living cells.
Keywords: BODIPY dyes  pH probe  fluorescent probe  probe for Fe3+
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QU Xing-Yu,BIAN Yong-Jun,BAI Yang,SHEN Zhen.A Visible BODIPY Probe for ‘Naked-Eye’ Detection of pH Value and Intracellular Fe3+[J].Chinese Journal of Inorganic Chemistry,2019,35(4):649-657.
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Chinese Journal of Inorganic Chemistry