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DNA Targeting Rigid Dinuclear Ruthenium-Arene Complexes
Author NameAffiliationE-mail
LI Ji College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China  
HAO Yuan-Yuan College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China  
QIAN Yong College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China  
XUE Xu-Lin College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China  
SU Zhi College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China liuhongke@njnu.edu.cn 
LIU Hong-Ke College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210023, China
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China 		zhisu@njnu.edu.cn 
Abstract: Three dinuclear Ru(Ⅱ)-arene complexes[Ru2(η6-p-bip)2(1,3-bib)2XY]X2 (X=Y=Cl- (1), X=Y=Br- (2), X=I- and Y=Cl- (3); 1,3-bib=1,3-di(1H-imidazol-1-yl)benzene, p-bip=biphenyl) were synthesized and fully characterized by 1H NMR and ESI-MS. Single crystal X-ray diffractions studies showed that complex 1 owns a rigid M2L2 bowl-like structure, where one Cl- is trapped inside the cavity to balance the charge. Complex 3 showed the best anticancer activities among complexes 1~3. The IC50 value of 3 towards to human lung cancer cells (A549) reached to 13.9 μmol·L-1, which is comparable to that of cisplatin (IC50=15.2 μmol·L-1). Complexes 1~3 have shown strong interactions with DNA and could induce the unwinding of the DNA superhelix structure.
Keywords: Ru-arene complexes  crystal structure  anticancer activity  interaction with DNA
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LI Ji,HAO Yuan-Yuan,QIAN Yong,XUE Xu-Lin,SU Zhi,LIU Hong-Ke.DNA Targeting Rigid Dinuclear Ruthenium-Arene Complexes[J].Chinese Journal of Inorganic Chemistry,2019,35(8):1500-1508.
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Chinese Journal of Inorganic Chemistry