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| Simultaneous Detection of Dopamine and Uric Acid Based on Chiral MOF and Acetylene Black Modified Electrode |
| Author Name | Affiliation | E-mail | | FANG Zhi-Li | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | fangzhili1972@126.com | | WANG Ping | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | | | LIU Sheng-Dong | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | | | WANG Xin | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | | | NIE Qi-Xiang | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | | | YANG Shao-Ming | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | | | XU Wen-Yuan | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | | | ZHOU Mei-Hua | School of Materials Science and Engineer, East China Jiaotong University, Nanchang 330013, China | |
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| Abstract: The chiral metal-organic framework, HMOF-Zn, with a large one-dimensional chiral channel and acetylene black (AB) were chosen as electrode materials to modify glassy carbon electrode (GCE) via a simple electrochemical method, denoted as HMOF-Zn@AB-Nafion-GCE. The HMOF-Zn@AB-Nafion-GCE sensor was used for simultaneous detection of dopamine (DA) and uric acid (UA). The experimental results showed that the HMOF-Zn@AB-Nafion-GCE sensor had high sensitivity and selectivity for UA and DA. And it was found that it exhibited higher sensitivity for DA than for UA on HMOF-Zn@AB-Nafion-GCE sensor. The high sensitivity and good selectivity of HMOF-Zn@AB-Nafion-GCE sensor for DA and UA are attributed to the synergistic effect of the large surface of HMOF-Zn, the bonding interaction between the analytes (DA or UA) and HMOF-Zn as well as the high conductivity of AB. At the same time, the proposed sensor exhibited excellent linear responses to DA and UA under optimized conditions. The detection ranges were 0.15~2.5 μmol·L-1 for DA and 0.2~4 μmol·L-1 for UA, with the detection limits of 0.003 and 0.02 μmol·L-1, respectively. Moreover, the high reproducibility of the sensor was obtained in all the experiments. The sensor was also successfully applied to the determination of DA in dopamine hydrochloride injection and UA in human urine sample. |
| Keywords: chirality metal-organic framework dopamine uric acid electrochemistry |
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| FANG Zhi-Li,WANG Ping,LIU Sheng-Dong,WANG Xin,NIE Qi-Xiang,YANG Shao-Ming,XU Wen-Yuan,ZHOU Mei-Hua.Simultaneous Detection of Dopamine and Uric Acid Based on Chiral MOF and Acetylene Black Modified Electrode[J].Chinese Journal of Inorganic Chemistry,2020,36(1):139-147. |
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