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| Preparation of nanoscale hafnium-containing metal-organic frameworks for X-ray-promoted chemodynamic synergistic therapy |
| Author Name | Affiliation | E-mail | | XIAO Kang | State Key Laboratory of Organic Electronics and Information Displays, School of Materials Science & Engineering, Nanjing University of Posts & Telecommunications, Nanjing 210023, China | | | XIE Wang-Wang | State Key Laboratory of Organic Electronics and Information Displays, School of Materials Science & Engineering, Nanjing University of Posts & Telecommunications, Nanjing 210023, China | | | LIU Xiang-Mei | State Key Laboratory of Organic Electronics and Information Displays, School of Materials Science & Engineering, Nanjing University of Posts & Telecommunications, Nanjing 210023, China | iamxmliu@njupt.edu.cn |
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| Abstract: Nanoscale hafnium-containing metal-organic frameworks (Hf-nMOFs) with octahedral (Hf-MOFs-1) and sheet-like (Hf-MOFs-2) structures were synthesized by a solvothermal method using hafnium clusters as the connection point of the MOF, rigid dicarboxylic ligand 2,2'-bipyridyl-5,5'-dicarboxylic acid as the connector, acetic acid or trifluoroacetic acid and water as the structural regulator. Subsequently, a post-modification method was used to incorporate Fe3+ into the backbone of Hf-nMOFs, leading to the creation of multifunctional nMOFs, designated as Hf-Fe-MOFs-1 and Hf-Fe-MOFs-2. In a mimic tumor microenvironment, the detection of hydroxyl radicals showed that X-ray irradiation significantly increased the generation efficiency of hydroxyl radicals in both Hf-Fe-MOFs-1 and Hf-Fe-MOFs-2, with a more generation ability of sheet-like Hf-Fe-MOFs-2 than that of octahedral Hf-Fe-MOFs-1. Additionally, cellular assays demonstrated successful uptake of the Hf-nMOFs by cells and confirmed their efficacy in achieving low-dose X-ray-promoted chemodynamic synergistic therapy. |
| Keywords: hafnium-containing metal-organic frameworks Fenton reaction hydroxyl radical chemodynamic therapy synergistic therapy |
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| XIAO Kang,XIE Wang-Wang,LIU Xiang-Mei.Preparation of nanoscale hafnium-containing metal-organic frameworks for X-ray-promoted chemodynamic synergistic therapy[J].Chinese Journal of Inorganic Chemistry,2023,39(11):2033-2041. |
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