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| Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes |
| Author Name | Affiliation | E-mail | | DENG Xin | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | ZHANG Fu-Xing | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | zfx8056@163.com | | QING Jing-Jing | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | YANG Ge | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | HE Fan | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | HE Li-Fang | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | LIU Zhi-Hui | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | HOU Shuai-Peng | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | |
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| Abstract: Two benzohydroxamic acid organotin complexes[(o-Cl-C6H4CH2)2Sn(C6H5CONO)2] (1) and[(o-CH3-C6H4CH2)2Sn(C6H5CONO) (C6H5COO)] (2) were synthesized by solvothermal method using methanol as a solvent. Complexes 1 and 2 were characterized by elemental analysis, IR, 1H NMR, thermogravimetric analysis, single-crystal X-ray diffraction, etc. The study on the complexes has been performed with quantum chemistry calculation and in vitro anticancer activity. The results show that the two complexes are monotin nuclear structures; complexes 1 and 2 are the six-coordinated distorted octahedron configuration and seven-coordinated distorted triangular bipyramid configuration, respectively. Complex 1 showed stronger inhibitory activity on human cervical cancer cells (HeLa), hepatoma cells (HuH-7), and lung adenocarcinoma cells (H1975) than cisplatin, while complex 2 showed much weaker inhibitory activity. |
| Keywords: bis(o-chlorobenzyl)tin bis(benzohydroxamic acid) complex bis(o-methylbenzyl)tin benzohydroxamic acid and benzoic acid mixed-ligand complex crystal structure quantum chemistry in vitro antitumor activity |
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| DENG Xin,ZHANG Fu-Xing,QING Jing-Jing,YANG Ge,HE Fan,HE Li-Fang,LIU Zhi-Hui,HOU Shuai-Peng.Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes[J].Chinese Journal of Inorganic Chemistry,2023,39(11):2083-2090. |
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