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| Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle |
| Author Name | Affiliation | E-mail | | QU Botao | School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China | | | WANG Qian | School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China | | | NING Xiaogang | School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China | | | ZHOU Yuxin | School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China | | | ZHANG Ruiping | The Radiology Department of First Hospital of Shanxi Medical University, Taiyuan 030001, China | beyondthj@163.com,zrp_7142@sxmu.edu.cn |
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| Abstract: A dual-targeting melanin nanoparticle (MNP-TPP-HA) was constructed by grafting the carboxyl groups of hyaluronic acid (HA) and (4carboxybutyl) triphenylphosphonium bromide (TPP) onto the surface of polyethylene glycol-amino (PEG-NH2) modified MNP based on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS) reaction, endowing melanin with the ability of dual active targeting. The fluorescence imaging of in vitro three-dimensional (3D) tumor models and in vivo photoacoustic imaging (PAI) all reveal the excellent target penetration ability of MNP-TPP-HA. |
| Keywords: dual-targeting melanin photoacoustic imaging penetration ability |
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| QU Botao,WANG Qian,NING Xiaogang,ZHOU Yuxin,ZHANG Ruiping.Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle[J].Chinese Journal of Inorganic Chemistry,2024,40(5):1025-1032. |
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