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| Glucose-modified bis-Schiff bases: Synthesis and bio-activities in Alzheimer′s disease therapy |
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| Abstract: The dyshomeostasis of metal ions is one of the pathogeneses of Alzheimer's disease (AD), and metal chelation therapy is a promising approach for the treatment of AD. In this work, three glucose-modified bis-Schiff bases were designed and synthesized. Their biological activities in treating AD in vitro were measured by turbidity assay, HRP/Amplex Red assay, fluorescent probe of DCFH-DA, NBT analysis, and MTT assay. The results were compared with cliquinol (CQ) and non-glucose-modified analogues. It was found that the glucose modified bis-Schiff bases had more efficient bio-activities in inhibiting metal ions (Cu2+, Zn2+) induced Aβ1-40 aggregation, decreasing the level of reactive oxygen species (ROS) in Cu2+-Aβ treated PC 12 cells, increasing the activity of superoxide dismutase in Cu2+-Aβ treated PC 12 cells and attenuating the cytotoxicity mediated by metal ions induced Aβ aggregation than CQ. The toxicity of glucose-modified bis-Schiff bases was lower than that of non-glucose functionalized analogues. The bio-activities of glucose-modified bis-Schiff bases on anti-oxidative and improving the survival rate of PC12 cells treated with Aβ and metal ions, were superior to those of non-glucose-modified analogues. |
| Keywords: synthesis glucose Alzheimer′s disease bis-Schiff base anti-oxidant |
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| SUN Bin,JIANG Heyan.Glucose-modified bis-Schiff bases: Synthesis and bio-activities in Alzheimer′s disease therapy[J].Chinese Journal of Inorganic Chemistry,2025,41(7):1338-1350. |
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