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| Terbium complex electrochemiluminescent emitters: Synthesis and application in the detection of epinephrine |
| Author Name | Affiliation | E-mail | | WANG Cun | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | XU Shaohan | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | ZHANG Yuqian | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | ZHANG Yaoyao | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | GONG Tao | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | WEN Rong | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | LIAO Yuhang | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | | | REN Yanrong | Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China | renyr@cque.edu.cn |
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| Abstract: To accurately detect epinephrine (EP), in this work, three lanthanide terbium complexes (α -Tb-CCP, β-Tb-CCP, and γ-Tb-CCP) as cathode electrochemiluminescence (ECL) luminophores were synthesized via a simple hydrothermal synthesis method, and the β-Tb-CCP with the highest ECL intensity was chosen. The highest ECL signal of β-Tb-CCP is mainly attributed to its small size and surface aperture. Finally, a sensitive ECL sensor for EP detection was constructed with β-Tb-CCP as the luminophore, EP as the signal quencher, and flower-shaped zinc oxide as the ECL signal stabilizer and co-reaction accelerator. In a range of 0.1 pmol·L-1 to 10 mmol·L-1, the ECL intensity difference ΔI (ΔI=I0-I, where I0 and I correspond to the blank ECL intensity without EP and with EP, respectively) showed a good quantitative linear relationship with the logarithm of EP concentration (lg c). The linear equation was ΔI=684.3lg c+9 443.0 (R2=0.9978), and the detection limit was 18.2 fmol·L-1 (S/N=3). In addition, the detection results of EP hydrochloride injection were 0.954 mg:1 mL and 4.883 mg:5 mL, which were close to the declared EP contents in the injection. |
| Keywords: terbium complex electrochemiluminescence epinephrine sensor |
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| WANG Cun,XU Shaohan,ZHANG Yuqian,ZHANG Yaoyao,GONG Tao,WEN Rong,LIAO Yuhang,REN Yanrong.Terbium complex electrochemiluminescent emitters: Synthesis and application in the detection of epinephrine[J].Chinese Journal of Inorganic Chemistry,2025,41(7):1351-1360. |
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